Medullary thyroid carcinoma cell lines contain a self-renewing CD133+ population that is dependent on ret proto-oncogene activity.

@article{Zhu2010MedullaryTC,
  title={Medullary thyroid carcinoma cell lines contain a self-renewing CD133+ population that is dependent on ret proto-oncogene activity.},
  author={Wen Xue Zhu and Tao Hai and Lei Ye and G. J. Cote},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2010},
  volume={95 1},
  pages={439-44}
}
CONTEXT Medullary thyroid carcinoma (MTC) is a cancer of the parafollicular C cells commonly caused by an inherited or acquired RET proto-oncogene mutation. Therapeutic resistance and recurrence of the disease imply the presence of cancer stem cells in MTC. OBJECTIVE In this study, we sought to identify and characterize cancer stem cell-like cells in MTC. MAIN OUTCOME MEASURES The characterization of stem cell properties was performed using immunostaining, flow cytometry, sphere formation… CONTINUE READING

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