Medullary circuits for nociceptive modulation.

  title={Medullary circuits for nociceptive modulation.},
  author={Peggy Mason},
  journal={Current opinion in neurobiology},
  volume={22 4},
Neurons in the medullary raphe are critical to opioid analgesia through descending projections to the dorsal horn. Work in anesthetized rats led to the postulate that nociceptive suppression results from tonic activation of nociceptive-inhibiting neurons and tonic inhibition of nociceptive-facilitating neurons. However, morphine does not cause tonic changes in raphe neuronal firing in unanesthetized rodents. Recent work suggests that a drop in activity of nociceptive-inhibiting neurons… CONTINUE READING

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