Medroxyprogesterone Acetate Regulates HIV-1 Uptake and Transcytosis but Not Replication in Primary Genital Epithelial Cells, Resulting in Enhanced T-Cell Infection.

@article{Ferreira2015MedroxyprogesteroneAR,
  title={Medroxyprogesterone Acetate Regulates HIV-1 Uptake and Transcytosis but Not Replication in Primary Genital Epithelial Cells, Resulting in Enhanced T-Cell Infection.},
  author={Victor H C Ferreira and Sara E. Dizzell and Aisha Nazli and Jessica K. Kafka and Kristen M Mueller and Philip V. Nguyen and Michel J Tremblay and Alan W Cochrane and Charu Kaushic},
  journal={The Journal of infectious diseases},
  year={2015},
  volume={211 11},
  pages={1745-56}
}
Although clinical and experimental evidence indicates that female sex hormones and hormonal contraceptives regulate susceptibility to human immunodeficiency virus type 1 (HIV-1) infection, the underlying mechanism remains unknown. Genital epithelial cells (GECs) are the first cells to encounter HIV during sexual transmission and their interaction with HIV may determine the outcome of exposure. This is the first report that HIV uptake by GECs increased significantly in the presence of the… CONTINUE READING
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