Medium effects in antibody-catalyzed reactions.

  title={Medium effects in antibody-catalyzed reactions.},
  author={C. A. M. Lewis and Thomas Kraemer and Susan Robinson and Donald Hilvert},
  volume={253 5023},
Catalytic antibody technology has been used to explore the contribution of medium effects to the overall rate of an enzyme-catalyzed reaction. An antibody generated against a derivative of 2-acetamido-1,5-napthalenedisulfonate efficiently catalyzes the decarboxylation of 5-nitro-3-carboxybenzisoxazole. This unimolecular reaction is not susceptible to general acid-base catalysis but is highly sensitive to microenvironment; thus, it provides a simple chemical model for biologically important… CONTINUE READING