• Corpus ID: 20320419

Medium chain triglyceride ketogenic diet in neurological and metabolic disorders

@inproceedings{Augustin2017MediumCT,
  title={Medium chain triglyceride ketogenic diet in neurological and metabolic disorders},
  author={Katrin Augustin and Aziza Khabbush and Sophie Williams and Simon Eaton and Michael R. Orford and J. Helen Cross and Simon J R Heales and Matthew C. Walker and Robin S. B. Williams},
  year={2017}
}
Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, TW20 OEX, UK; Clinical and Molecular Genetics Unit, University College London Institute of Child Health, London, WC1N 3JH, UK. Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, WC1N 3BG, UK; Neurosciences Unit, UCL Institute of Child Health, London, WC1N 1EH, UK. *These authors contributed equally 
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SHOWING 1-10 OF 96 REFERENCES

The ketogenic diet: metabolic influences on brain excitability and epilepsy

Ketogenic diets: from cancer to mitochondrial diseases and beyond

The employment of dietary strategies such as ketogenic diets, which force cells to alter their energy source, has shown efficacy in the treatment of several diseases. Ketogenic diets are composed of

The ketogenic diet component decanoic acid increases mitochondrial citrate synthase and complex I activity in neuronal cells

C10 may mimic the mitochondrial proliferation associated with the KD and raises the possibility that formulations based on this fatty acid could replace a more complex diet.

The pleiotropic effects of decanoic acid treatment on mitochondrial function in fibroblasts from patients with complex I deficient Leigh syndrome

The effects of C10 were investigated in primary fibroblasts from a cohort of patients with Leigh syndrome caused by nuclear-encoded defects of respiratory chain complex I, using mitochondrial respiratory chain enzyme assays, gene expression microarray, qPCR and flow cytometry.

Tissue Specific Impacts of a Ketogenic Diet on Mitochondrial Dynamics in the BTBRT+tf/j Mouse

Examination of the impact of a ketogenic diet on mitochondrial dynamics in the liver and brain of the BTBR mouse model of ASD found that consumption of a KD exerts highly tissue-specific effects, ultimately increasing mitochondrial turnover in the Liver, while gene and protein expression in the brain remaining tightly regulated.

Ketogenic diet and other dietary treatments for epilepsy.

The randomised controlled trials discussed in this review show promising results for the use of KDs in epilepsy, however, the limited number of studies, small sample sizes and a sole paediatric population resulted in a poor overall quality of evidence.

Benefits of use, and tolerance of, medium-chain triglyceride medical food in the management of Japanese patients with Alzheimer’s disease: a prospective, open-label pilot study

The modified dose-titration method, starting with a low dose of Axona, decreased gastrointestinal adverse effects in Japanese patients, suggesting Axona might be effective for some relatively mildly affected patients with AD.

Seizure Control by Derivatives of Medium Chain Fatty Acids Associated with the Ketogenic Diet Show Novel Branching-Point Structure for Enhanced Potency

This study identifies a novel family of fatty acids, related to the MCT ketogenic diet, that show promise as new treatments for epilepsy control and possibly other MCTketogenic diet-responding conditions, such as Alzheimer disease.
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