Medium chain triglyceride ketogenic diet in neurological and metabolic disorders
@inproceedings{Augustin2017MediumCT, title={Medium chain triglyceride ketogenic diet in neurological and metabolic disorders}, author={Katrin Augustin and Aziza Khabbush and Sophie Williams and Simon Eaton and Michael R. Orford and J. Helen Cross and Simon J R Heales and Matthew C. Walker and Robin S. B. Williams}, year={2017} }
Centre for Biomedical Sciences, School of Biological Sciences, Royal Holloway University of London, Egham, TW20 OEX, UK; Clinical and Molecular Genetics Unit, University College London Institute of Child Health, London, WC1N 3JH, UK. Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London, WC1N 3BG, UK; Neurosciences Unit, UCL Institute of Child Health, London, WC1N 1EH, UK. *These authors contributed equally
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References
SHOWING 1-10 OF 96 REFERENCES
The ketogenic diet: metabolic influences on brain excitability and epilepsy
- Biology, MedicineTrends in Neurosciences
- 2013
Ketogenic diets: from cancer to mitochondrial diseases and beyond
- BiologyEuropean journal of clinical investigation
- 2016
The employment of dietary strategies such as ketogenic diets, which force cells to alter their energy source, has shown efficacy in the treatment of several diseases. Ketogenic diets are composed of…
The ketogenic diet component decanoic acid increases mitochondrial citrate synthase and complex I activity in neuronal cells
- BiologyJournal of neurochemistry
- 2014
C10 may mimic the mitochondrial proliferation associated with the KD and raises the possibility that formulations based on this fatty acid could replace a more complex diet.
Multi-dimensional Roles of Ketone Bodies in Fuel Metabolism, Signaling, and Therapeutics.
- BiologyCell metabolism
- 2017
The pleiotropic effects of decanoic acid treatment on mitochondrial function in fibroblasts from patients with complex I deficient Leigh syndrome
- Biology, MedicineJournal of Inherited Metabolic Disease
- 2016
The effects of C10 were investigated in primary fibroblasts from a cohort of patients with Leigh syndrome caused by nuclear-encoded defects of respiratory chain complex I, using mitochondrial respiratory chain enzyme assays, gene expression microarray, qPCR and flow cytometry.
Seizure control by ketogenic diet-associated medium chain fatty acids
- Biology, MedicineNeuropharmacology
- 2013
Tissue Specific Impacts of a Ketogenic Diet on Mitochondrial Dynamics in the BTBRT+tf/j Mouse
- BiologyFront. Physiol.
- 2016
Examination of the impact of a ketogenic diet on mitochondrial dynamics in the liver and brain of the BTBR mouse model of ASD found that consumption of a KD exerts highly tissue-specific effects, ultimately increasing mitochondrial turnover in the Liver, while gene and protein expression in the brain remaining tightly regulated.
Ketogenic diet and other dietary treatments for epilepsy.
- Medicine, PsychologyThe Cochrane database of systematic reviews
- 2016
The randomised controlled trials discussed in this review show promising results for the use of KDs in epilepsy, however, the limited number of studies, small sample sizes and a sole paediatric population resulted in a poor overall quality of evidence.
Benefits of use, and tolerance of, medium-chain triglyceride medical food in the management of Japanese patients with Alzheimer’s disease: a prospective, open-label pilot study
- MedicineClinical interventions in aging
- 2016
The modified dose-titration method, starting with a low dose of Axona, decreased gastrointestinal adverse effects in Japanese patients, suggesting Axona might be effective for some relatively mildly affected patients with AD.
Seizure Control by Derivatives of Medium Chain Fatty Acids Associated with the Ketogenic Diet Show Novel Branching-Point Structure for Enhanced Potency
- BiologyThe Journal of Pharmacology and Experimental Therapeutics
- 2015
This study identifies a novel family of fatty acids, related to the MCT ketogenic diet, that show promise as new treatments for epilepsy control and possibly other MCTketogenic diet-responding conditions, such as Alzheimer disease.