Medium-chain fatty acids stimulate interleukin-8 production in Caco-2 cells with different mechanisms from long-chain fatty acids.

@article{Tanaka2001MediumchainFA,
  title={Medium-chain fatty acids stimulate interleukin-8 production in Caco-2 cells with different mechanisms from long-chain fatty acids.},
  author={Satoshi Tanaka and Osamu Saitoh and Keiichi Tabata and Ryoichi Matsuse and Kuniyuki Kojima and Kazunori Sugi and Ken Nakagawa and Masanobu Kayazawa and Tsutomu Teranishi and Kazuo Uchida and Ichiro Hirata and Ken-ichi Katsu},
  journal={Journal of gastroenterology and hepatology},
  year={2001},
  volume={16 7},
  pages={748-54}
}
BACKGROUND AND AIM It has been suggested that dietary fat exacerbates intestinal inflammation. We investigated the effect of fatty acids on interleukin (IL)-8 production in a human intestinal epithelial cell line (Caco-2). METHODS The cells were cultured as monolayers on microporous membranes in culture inserts. Oleic acid (OA), capric acid (CA), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) were applied to the apical compartment of Caco-2 cell monolayers. The concentration of IL… CONTINUE READING
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