Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor.

  title={Medium-chain fatty acid-sensing receptor, GPR84, is a proinflammatory receptor.},
  author={Masakatsu Suzuki and Sachiko Takaishi and Miyuki Nagasaki and Yoshiko Onozawa and Ikue Iino and Hiroaki Maeda and Tomoaki Komai and Tomiichiro Oda},
  journal={The Journal of biological chemistry},
  volume={288 15},
G protein-coupled receptor 84 (GPR84) is a putative receptor for medium-chain fatty acids (MCFAs), whose pathophysiological roles have not yet been clarified. Here, we show that GPR84 was activated by MCFAs with the hydroxyl group at the 2- or 3-position more effectively than nonhydroxylated MCFAs. We also identified a surrogate agonist, 6-n-octylaminouracil (6-OAU), for GPR84. These potential ligands and the surrogate agonist, 6-OAU, stimulated [(35)S]GTP binding and accumulated… CONTINUE READING
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