Medium- and short-chain dehydrogenase/reductase gene and protein families

@article{Staab2008MediumAS,
  title={Medium- and short-chain dehydrogenase/reductase gene and protein families},
  author={Claudia A. Staab and Mikko Hellgren and Jan Olov H{\"o}{\"o}g},
  journal={Cellular and Molecular Life Sciences},
  year={2008},
  volume={65},
  pages={3950-3960}
}
Abstract.Alcohol dehydrogenase 3 (ADH3) is highly conserved, ubiquitously expressed in mammals and involved in essential cellular pathways. A large active site pocket entails special substrate specificities: shortchain alcohols are poor substrates, while medium-chain alcohols and particularly the glutathione adducts S-hydroxymethylglutathione (HMGSH) and S-nitrosoglutathione (GSNO) are efficiently converted under concomitant use of NAD+/NADH. By oxidation of HMGSH, the spontaneous glutathione… Expand
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