Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial

  title={Mediterranean diet improves cognition: the PREDIMED-NAVARRA randomised trial},
  author={Elena Hernandez Martinez-Lapiscina and Pedro Clavero and Estefan{\'i}a Toledo and Ram{\'o}n Estruch and Jordi Salas-Salvad{\'o} and Beatriz San Juli{\'a}n and Ana S{\'a}nchez-Ta{\'i}nta and Emilio Ros and Cinta Valls-Pedret and Miguel Angel Mart{\'i}nez-Gonz{\'a}lez},
  journal={Journal of Neurology, Neurosurgery \& Psychiatry},
  pages={1318 - 1325}
Objective Previous observational studies reported beneficial effects of the Mediterranean diet (MedDiet) on cognitive function, but results were inconsistent. We assessed the effect on cognition of a nutritional intervention using MedDiets in comparison with a low-fat control diet. Methods We assessed 522 participants at high vascular risk (44.6% men, age 74.6 ± 5.7 years at cognitive evaluation) enrolled in a multicentre, randomised, primary prevention trial (PREDIMED), after a nutritional… 

Mediterranean Diet and Age-Related Cognitive Decline: A Randomized Clinical Trial.

In an older population, a Mediterranean diet supplemented with olive oil or nuts is associated with improved cognitive function, and this work is likely to be a first step towards addressing the underlying cause of dementia in patients at high cardiovascular risk.

The Mediterranean Diet and Cognitive Function among Healthy Older Adults in a 6-Month Randomised Controlled Trial: The MedLey Study

Examining the effect of a Mediterranean dietary pattern for six months on aspects of cognitive function in a randomised controlled intervention trial that extended for a duration of 18 months did not find evidence of a beneficial effect of the MedDiet intervention on cognitive function among healthy older adults.

A Prospective Study Of Mediterranean Diet And Cognitive Decline

MedDiet adherence was not significantly associated with cognitive change among ARIC participants, and there was no significant relationship between MedDiet Score and cognitive change in univariate, demographic, or fully adjusted models.

Effect of the Mediterranean diet on cognition and brain morphology and function: a systematic review of randomized controlled trials.

This first published review of randomized controlled trials investigating Mediterranean diet effects on cognition or brain morphology and function with an additional focus on intervention diet quality found that the Mediterranean diet modulates the effect of several genotypes associated with dementia risk for some cognitive outcomes, with mixed results.

A Mediterranean Diet to Improve Cardiovascular and Cognitive Health: Protocol for a Randomised Controlled Intervention Study

Evaluated whether a Mediterranean diet with adequate dairy and calcium can improve cardiovascular and cognitive function in an at-risk population, and thereby reduce risk of cardiovascular disease (CVD) and cognitive decline, and may contribute to revisions of national dietary guidelines.

A Mediterranean diet supplemented with dairy foods improves mood and processing speed in an Australian sample: results from the MedDairy randomized controlled trial

Evidence is provided that a Mediterranean diet supplemented with dairy foods may benefit cognitive function and psychological well-being in an ageing population at risk of dementia.

Mediterranean diet and cognitive function: The sun project

A higher adherence to the MedDiet might be associated with better cognitive function, however, observed differences were of small magnitude and further studies are needed to confirm this finding.

Adherence to Mediterranean Diet and Cognitive Abilities in the Greek Cohort of Epirus Health Study

Overall, no association was found between the MEDAS score and cognitive tests, which could be explained by the young mean age and high level of education of the participants.

The PREDIMED trial, Mediterranean diet and health outcomes: How strong is the evidence?




Mediterranean diet and cognitive function: a French study.

This study did not find support for a beneficial effect of MedDiet adherence on cognitive function, irrespective of educational level, which is the strongest indicator of cognitive reserve.

Adherence to a Mediterranean-type dietary pattern and cognitive decline in a community population.

The Mediterranean dietary pattern as captured by the MedDiet scoring system may reduce the rate of cognitive decline with older age.

Long-term adherence to the Mediterranean diet is associated with overall cognitive status, but not cognitive decline, in women.

In summary, long-term MeDi adherence was related to moderately better cognition but not with cognitive change in this very large cohort of older women.

The Mediterranean diet is not related to cognitive change in a large prospective investigation: the PATH Through Life study.

  • N. CherbuinK. Anstey
  • Psychology, Medicine
    The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry
  • 2012
Adherence to Mediterranean diet was not found to be protective against cognitive decline but excessive caloric intake, and high intake of monounsaturated fats was predictive of mild cognitive impairment.

Adherence to a Mediterranean diet, cognitive decline, and risk of dementia.

Higher adherence to a Mediterranean diet was associated with slower MMSE cognitive decline but not consistently with other cognitive tests, and higher adherence was not associated with risk for incident dementia.

Effects of a Mediterranean-Style Diet on Cardiovascular Risk Factors

A large-scale feeding trial in high-risk participants to assess the effects of 2 Mediterranean diets, one supplemented with virgin olive oil and the other supplemented with mixed nuts, compared with a low-fat diet on cardiovascular outcomes.

Dietary antioxidants and long-term risk of dementia.

Higher intake of foods rich in vitamin E may modestly reduce long-term risk of dementia and AD.

Polyphenol-rich foods in the Mediterranean diet are associated with better cognitive function in elderly subjects at high cardiovascular risk.

Increased consumption of antioxidant-rich foods in general and of polyphenols in particular is associated with better cognitive performance in elderly subjects at high cardiovascular risk, and the results reinforce the notion that Mediterranean diet components might counteract age-related cognitive decline.