Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study.

  title={Mediterranean diet, traditional risk factors, and the rate of cardiovascular complications after myocardial infarction: final report of the Lyon Diet Heart Study.},
  author={Michel de Lorgeril and Patricia Salen and J. L. Mart{\'i}n and I Monjaud and Jacques Delaye and Nicole Mamelle},
  volume={99 6},
BACKGROUND The Lyon Diet Heart Study is a randomized secondary prevention trial aimed at testing whether a Mediterranean-type diet may reduce the rate of recurrence after a first myocardial infarction. [] Key Result In the Mediterranean diet group, CO 1 was reduced (14 events versus 44 in the prudent Western-type diet group, P=0.0001), as were CO 2 (27 events versus 90, P=0.0001) and CO 3 (95 events versus 180, P=0. 0002). Adjusted risk ratios ranged from 0.28 to 0.53.

Mediterranean-style diet is associated with reduced blood pressure variability and subsequent stroke risk in patients with coronary artery disease.

Among patients with CAD, a higher MDS is associated with a lower visit-to-visit BPV and with lower stroke risk, and a high MDS was an independent predictor for low systolic BPV.

The Efficacy of a Mediterranean Diet in Reducing the Risk of Cardiovascular and Cerebrovascular Disease Incidence and Mortality in Patients with Known Risk Factors

The Mediterranean diet has been shown to reduce the risk of cardiovascular disease incidence and mortality, and providers should advise patients without disease but with known risk factors to implement complete adherence to the Mediterranean diet for best risk reduction.

Primary prevention of cardiovascular disease with a Mediterranean diet.

Among persons at high cardiovascular risk, a Mediterranean diet supplemented with extra-virgin olive oil or nuts reduced the incidence of major cardiovascular events.

The Mediterranean-style diet for the prevention of cardiovascular diseases

Even small doses of omega-3 fatty acids might be very protective in the context of a diet rich in oleic acid, poor in saturated fats and low in omega-6 fatty acids (a dietary pattern characterising the traditional Mediterranean diet), underline the importance of the accompanying diet in any dietary strategy using fatty acid complements.

Dietary prevention of coronary heart disease: the Lyon Diet Heart Study.

The 46-month mean follow-up findings on the original report of the study on “Mediterranean α-linolenic acid–rich diet in secondary prevention of coronary heart disease,” the so-called Lyon Diet Heart Study, report the initial remarkably beneficial effects of the experimental dietary program persisted.

A Mediterranean-style diet, its components and the risk of heart failure: a prospective population-based study in a non-Mediterranean country

The tMED was not significantly associated withHF risk, but low meat, high fish and moderate alcohol intake were inversely associated with HF risk in the non-Mediterranean population.

Mediterranean diet adherence and synergy with acute myocardial infarction and its determinants: A multicenter case-control study in Italy

A synergistic effect does exist between poor adherence to the MD and the following risk factors: hypertension, hypercholesterolemia, BMI >25, diabetes and being a resident in central and northern Italy.



Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States

The data do not support the strong association between intake of saturated fat and risk of coronary heart disease suggested by international comparisons, but they are compatible with the hypotheses that saturatedfat and cholesterol intakes affect the risk of heart disease as predicted by their effects on blood cholesterol concentration.

Control of bias in dietary trial to prevent coronary recurrences: The Lyon diet heart study

Evidence is provided that the dietary modifications per se were protective, not other (including psychosocial) changes resulting from the participation to the trial, although the study cannot be completely shielded from minor biases.

Effects of Traditional Coronary Risk Factors on Rates of Incident Coronary Events in a Low‐Risk Population: The Adventist Health Study

The epidemiology of coronary heart disease in this low-risk California population appears to be at least qualitatively similar to that seen in other groups, although there was evidence that the effects of exercise and obesity may differ depending on whether fatal myocardial infarction and MI is the end point.

The 'diet heart' hypothesis in secondary prevention of coronary heart disease.

New and more specific dietary recommendations are clearly warranted in secondary prevention of coronary heart disease and should be more specific and more clearly defined and therefore different from those generally provided in the U.S.A. and Europe at present.


Data from the Chicago Western Electric Study show an inverse association between fish consumption and death from coronary heart disease, especially nonsudden death from myocardial infarction.

Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT).

The data of high precision show that the relationship between serum cholesterol and CHD is not a threshold one, with increased risk confined to the two highest quintiles, but rather is a continuously graded one that powerfully affects risk for the great majority of middle-aged American men.

Serum total cholesterol and long-term coronary heart disease mortality in different cultures. Twenty-five-year follow-up of the seven countries study.

The large difference in absolute CHD mortality rates at a given cholesterol level, however, indicates that other factors, such as diet, that are typical for cultures with a low CHD risk are also important with respect to primary prevention.

Nifedipine. Dose-related increase in mortality in patients with coronary heart disease.

In patients with coronary disease, the use of short-acting nifedipine in moderate to high doses causes an increase in total mortality, and other calcium antagonists may have similar adverse effects, in particular those of the dihydropyridine type.