Medin-amyloid: a recently characterized age-associated arterial amyloid form affects mainly arteries in the upper part of the body.

Abstract

Amyloid deposition occurs commonly in the aging aortic media. We recently found that a 50 amino acid amyloid fibril protein, which we called medin, forms the fibrils of this amyloid form. Medin is an internal fragment of the 364 long precursor lactadherin, which is expressed by several kinds of cells including vascular smooth muscle cells. With the use of… (More)

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