Medicolegal aspects of tetrazepam metabolism

@article{Pavlic2006MedicolegalAO,
  title={Medicolegal aspects of tetrazepam metabolism},
  author={Marion Pavlic and Kathrin Libiseller and Petra Grubwieser and Heinrich M. Schubert and Walter Rabl},
  journal={International Journal of Legal Medicine},
  year={2006},
  volume={121},
  pages={169-174}
}
The benzodiazepine tetrazepam is primarily muscle relaxant with comparably lower central sedating effects and is therefore commonly prescribed for muscle spasms of different origins. To evaluate tetrazepam metabolism, a study was conducted with ten healthy volunteers. Blood and urine samples were regularly collected after the intake of 50 mg tetrazepam. Toxicological analyses revealed that tetrazepam is also metabolized to diazepam and further to nordazepam, which has not yet been reported… 
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TLDR
It seems reasonable, at least from the pharmacokinetic point of view, to attribute pharmacologic activity of tetrazepam mainly to the parent drug.
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TLDR
It is concluded that replacing the 5-phenyl ring by a 5-cyclohexenyl ring leads to a relative dissociation of the pharmacological actions of the 1,4-BZDs.
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TLDR
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TLDR
It is concluded that tetrazepam exerts its muscle Relaxant activity by stimulating central BZD receptors, and presents the advantage of a wide dissociation between muscle relaxant and sedative potencies.
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TLDR
In cases of drug-facilitated crimes in which tetrazepam is involved, hair and beard analyses can be an important complement to urine analyses to document exposure, particularly if LC-MS/MS is used.
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TLDR
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TLDR
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TLDR
It is concluded that tetrazepam is a BZD receptor agonist; the molecular mechanisms which underly the low sedative potential of the drug cannot at present be explained by a particular interaction with either central or peripheral BzD binding sites, but may be related to the drug's relatively weak effect on 35S-t-butyl-bicyclophosphorothionate binding.
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TLDR
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