Medicolegal aspects of tetrazepam metabolism

@article{Pavlic2006MedicolegalAO,
  title={Medicolegal aspects of tetrazepam metabolism},
  author={Marion Pavlic and Kathrin Libiseller and Petra Grubwieser and Heinrich M. Schubert and Walter Rabl},
  journal={International Journal of Legal Medicine},
  year={2006},
  volume={121},
  pages={169-174}
}
The benzodiazepine tetrazepam is primarily muscle relaxant with comparably lower central sedating effects and is therefore commonly prescribed for muscle spasms of different origins. To evaluate tetrazepam metabolism, a study was conducted with ten healthy volunteers. Blood and urine samples were regularly collected after the intake of 50 mg tetrazepam. Toxicological analyses revealed that tetrazepam is also metabolized to diazepam and further to nordazepam, which has not yet been reported… 
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The literature data related to the occurrence, persistence, environmental fate and toxicity for non-target organisms of this group of pharmaceuticals are reviewed and the analytical methods developed for the determination of psychiatric medicines in environmental matrices are highlighted.
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Metabolic studies of tetrazepam based on electrochemical simulation in comparison to in vivo and in vitro methods.
TLDR
The present study demonstrates that this metabolic conversion of tetrazepam can also be predicted on the basis of a purely instrumental method, consisting of an electrochemical cell coupled to online liquid chromatography (LC) and mass spectrometry (MS).
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Potential false-positive results and false-negative results that occur with immunoassays of amphetamines, cannabinoids, cocaine, opiates, and phencyclidine and with alcohol, benzodiazepines, and tricyclic antidepressants are discussed.
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