Medicolegal aspects of tetrazepam metabolism

@article{Pavlic2006MedicolegalAO,
  title={Medicolegal aspects of tetrazepam metabolism},
  author={M. Pavlic and K. Libiseller and P. Grubwieser and H. Schubert and W. Rabl},
  journal={International Journal of Legal Medicine},
  year={2006},
  volume={121},
  pages={169-174}
}
  • M. Pavlic, K. Libiseller, +2 authors W. Rabl
  • Published 2006
  • Medicine
  • International Journal of Legal Medicine
  • The benzodiazepine tetrazepam is primarily muscle relaxant with comparably lower central sedating effects and is therefore commonly prescribed for muscle spasms of different origins. To evaluate tetrazepam metabolism, a study was conducted with ten healthy volunteers. Blood and urine samples were regularly collected after the intake of 50 mg tetrazepam. Toxicological analyses revealed that tetrazepam is also metabolized to diazepam and further to nordazepam, which has not yet been reported… CONTINUE READING
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    References

    SHOWING 1-10 OF 29 REFERENCES
    Biotransformation and pharmacokinetics of tetrazepam in man.
    • 9
    Tetrazepam: a benzodiazepine which dissociates sedation from other benzodiazepine activities. I. Psychopharmacological profile in rodents.
    • 23
    Plasma levels and pharmacokinetics of single and multiple dose of tetrazepam in healthy volunteers.
    • 6
    Comparative study in mice of tetrazepam and other centrally active skeletal muscle relaxants.
    • 18
    Bioavailability investigation of two different oral formulations of Tetrazepam.
    • 4
    Tetrazepam: a benzodiazepine which dissociates sedation from other benzodiazepine activities. II. In vitro and in vivo interactions with benzodiazepine binding sites.
    • 13
    Therapeutic and toxic blood concentrations of more than 800 drugs and other xenobiotics.
    • 386