Medicinal plants and their natural components as future drugs for the treatment of burn wounds: an integrative review

@article{Bahramsoltani2014MedicinalPA,
  title={Medicinal plants and their natural components as future drugs for the treatment of burn wounds: an integrative review},
  author={Roodabeh Bahramsoltani and Mohammad Hosein Farzaei and Roja Rahimi},
  journal={Archives of Dermatological Research},
  year={2014},
  volume={306},
  pages={601-617}
}
Burn wound healing is a complicated process including inflammation, re-epithelialization, granulation, neovascularization and wound contraction. Several biochemicals are involved in burn healing process including antioxidants, cytokines and liver and kidney damage biomarkers. Although several preparations are available for the management of burn wound, there is still a necessity of researching for efficacious medicine. The aim of the present study was to evaluate herbal preparations and their… 
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References

SHOWING 1-10 OF 79 REFERENCES
Practices in Wound Healing Studies of Plants
TLDR
The wound healing efficacies of various herbal extracts have been evaluated in excision, incision, dead space, and burn wound models.
Wound Healing Potential of Pterocarpus Santalinus Linn: A Pharmacological Evaluation
TLDR
A pharmacological study to evaluate the toxicity as well as wound-healing potential in animal studies of P. santalinus ointment, finding it safe and effective in treating acute wounds in animal models.
Efficacy of topical application of alcoholic extract of yarrow in the healing process of experimental burn wounds in rabbit
Medicinal herbs have been used for thousands of years to heal burn wounds, skin ulcers, and sores. The yarrow plant (Achillea millefolium) is a well-known medicinal plant. The aim of this study was
Identification of Major Active Ingredients Responsible for Burn Wound Healing of Centella asiatica Herbs
  • Fang Wu, Difei Bian, Yue Dai
  • Chemistry, Medicine
    Evidence-based complementary and alternative medicine : eCAM
  • 2012
TLDR
Interestingly, in contrast to prevalent postulations, asiaticoside and madecassoside themselves, rather than their corresponding metabolites as iatic acid andmadecassic acid, are recognized as the main active constituents of C. asiaticsa herbs responsible for burn wound healing.
Effect of Michelia champaca Linn flowers on burn wound healing in wistar rats
TLDR
Ethanolic extract of M. champaca flowers were used to evaluate its burn wound healing activity in rats and wound contraction rate was improved significantly by topical and oral administration and the period of epithelialisation was reduced in the burn wound model.
In vivo wound-healing efficacy and antioxidant activity of Achyranthes aspera in experimental burns
TLDR
The methanol leaf extract of A. aspera showed excellent wound-healing activities which has great potential for development of plant-based product.
Investigation of wound healing activity of Lantana camara L. in Sprague dawley rats using a burn wound model
TLDR
The data suggest that L.camara has antimicrobial activity but not wound healing promoting activity on burn wound, and Lantana oil is used for the treatment of skin itches and as an antiseptic for wounds.
Celosia argentea Linn. leaf extract improves wound healing in a rat burn wound model
TLDR
A salutary action of the CA extract is demonstrated on wound healing, and it is suggested that this may be due to mitogenic and motogenic promotion of dermal fibroblasts.
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