Medicinal plants and bioactive natural compounds in the treatment of non‐alcoholic fatty liver disease: A clinical review

  title={Medicinal plants and bioactive natural compounds in the treatment of non‐alcoholic fatty liver disease: A clinical review},
  author={Mohammad Bagherniya and Valerio Nobili and Christopher N. Blesso and Amirhossein Sahebkar},
  journal={Pharmacological Research},

Figures and Tables from this paper

Plant-Based Foods and Their Bioactive Compounds on Fatty Liver Disease: Effects, Mechanisms, and Clinical Application

Overall, certain plant-based foods are promising natural sources of bioactive compounds to prevent and alleviate fatty liver disease.

Nutraceutical Approach to Non-Alcoholic Fatty Liver Disease (NAFLD): The Available Clinical Evidence

Silymarin, vitamin E and vitamin D, polyunsaturated fatty acids of the omega-3 series, coenzyme Q10, berberine and curcumin, if well dosed and administered for medium–long periods, and associated to lifestyle changes, could exert positive effects on NAFLD andNAFLD-related parameters.

Curcuminoids plus piperine improve nonalcoholic fatty liver disease: A clinical trial

In order to improve the bioavailability of curcumin, it was coadministered with piperine and the effects of this bioavailability‐enhancedCurcumin on serum hepatic enzymes, lipid profile, and glycemic indices in patients with NAFLD are investigated.

The Effect of Herbal Medicine and Natural Bioactive Compounds on Plasma Adiponectin: A Clinical Review.

It can be concluded that medicinal plants, and herbal bioactive compounds, particularly curcumin, anthocyanins, resveratrol, soy, walnut, and dihydromyricetin can be used as adjunct or complementary therapeutic agents to increase plasma adiponectin, which could potentially prevent and treat NCDs.

Protective Effect and Mechanism of Plant-Based Monoterpenoids in Non-alcoholic Fatty Liver Diseases.

This review provides a reference for the development of NAFLD drugs as a research guideline for the potential uses of plant monoterpenoids and demonstrated that they are effective and safe candidate drugs forNAFLD.

The Effects of Medicinal Plants and Bioactive Natural Compounds on Homocysteine

The beneficial effects of medicinal plants as natural, inexpensive, and accessible agents on homocysteine levels based on animal studies were highlighted, suggesting that more well-designed trials are warranted.

Natural Compounds for Counteracting Nonalcoholic Fatty Liver Disease (NAFLD): Advantages and Limitations of the Suggested Candidates

Some of the reported compounds with beneficial properties in NAFLD are reviewed, namely, coffee (and its components), tormentic acid, verbascoside, and silymarin, to provide details about their protective effects, their mechanism of action in ameliorating the critical pathological events involved inNAFLD, and their clinical applications.

Design of Hepatic Targeted Drug Delivery Systems for Natural Products: Insights into Nomenclature Revision of Nonalcoholic Fatty Liver Disease.

The up-to-date developments of the NAFLD-HTDDS based on natural products are summarized and viewpoints for the establishment of more stringent anti-NAFLD natural-product-targeted nanoformulations are provided.

Medicinal Plants and Phytochemicals Regulating Insulin Resistance and Glucose Homeostasis in Type 2 Diabetic Patients: A Clinical Review.

Most of the herbal bioactive compounds including resveratrol, garlic, curcumin, cinnamon, ginger, nuts, berberine, anthocyanin, soybean, flaxseed, vegetable oils, and soluble fibers have benefit in their efficacy for decreasing IR, fasting blood sugar (FBS), fasting insulin and HbA1c.



Is There a Role for Curcumin Supplementation in the Treatment of Non-Alcoholic Fatty Liver Disease? The Data Suggest Yes.

The present review summarizes the current knowledge on the impact of curcumin supplementation on different biochemical and histopathological features of NAFLD.

Relevant Aspects of Nutritional and Dietary Interventions in Non-Alcoholic Fatty Liver Disease

This review presents a compilation of the scientific evidence found in the last years showing the results of interventions in lifestyle, diet, and behavioral therapies and research results in human, animal and cell models.

Efficacy and Safety of Phytosomal Curcumin in Non-Alcoholic Fatty Liver Disease: A Randomized Controlled Trial.

Short-term supplementation with curcumin improves liver fat and transaminase levels in patients with NAFLD and was safe and well tolerated during the course of trial.

Dietary Anthocyanins as Nutritional Therapy for Nonalcoholic Fatty Liver Disease

The evidence evaluating the mechanisms of action of ACNs on hepatic lipid metabolism in different experimental setting: in vitro, in vivo, and in human trials is summarized and a working model depicting the possible mechanisms underpinning the beneficial effects of ACN in NAFLD is proposed.

New evidence for the therapeutic potential of curcumin to treat nonalcoholic fatty liver disease in humans

The findings provide new evidence for the therapeutic potential of curcumin to treat human NAFLD and the development of a preventive treatment targeting human circulating monocytes and liver macrophages as well as peripheral and hepatic CD4+ cells requires additional research.

Treatment of Non‐alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo‐controlled Trial

Findings of the present proof‐of‐concept trial suggested improvement of different features of NAFLD after a short‐term supplementation with curcumin.

Diets and nonalcoholic fatty liver disease: the good and the bad.

Effect of silymarin plus vitamin E in patients with non-alcoholic fatty liver disease. A randomized clinical pilot study.

Treatment with silymarin plus vitamin E and a hypocaloric diet ameliorate function hepatic test, and non-invasive NAFLD index shows sily marin can be an alternative valid therapeutic option particularly when other drugs are not indicated or have failed or as a complementary treatment associated with other therapeutic programs.

The Potential Mechanisms of Berberine in the Treatment of Nonalcoholic Fatty Liver Disease

Increase of insulin sensitivity, regulation of adenosine monophosphate-activated protein kinase (AMPK) pathway, improvement of mitochondrial function, alleviation of oxidative stress, LDLR mRNA stabilization, and regulation of gut microenvironment are the major targets of BBR in the treatment of NAFLD.

Curcumin Lowers Serum Lipids and Uric Acid in Subjects With Nonalcoholic Fatty Liver Disease: A Randomized Controlled Trial

Results of the present trial suggest that curcumin supplementation reduces serum lipids and uric acid concentrations in patients with NAFLD.