Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides

@article{Wasser2002MedicinalMA,
  title={Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides},
  author={Solomon P. Wasser},
  journal={Applied Microbiology and Biotechnology},
  year={2002},
  volume={60},
  pages={258-274}
}
  • S. Wasser
  • Published 1 November 2002
  • Biology, Medicine
  • Applied Microbiology and Biotechnology
Abstract. [] Key Result These polysaccharides are of different chemical composition, with most belonging to the group of β-glucans; these have β-(1→3) linkages in the main chain of the glucan and additional β-(1→6) branch points that are needed for their antitumor action. High molecular weight glucans appear to be more effective than those of low molecular weight. Chemical modification is often carried out to improve the antitumor activity of polysaccharides and their clinical qualities (mostly water…

Antitumor and immunomodulatory activities of medicinal mushroom polysaccharides and polysaccharide-protein complexes in animals and humans (Review)

. Th e number of mushrooms on Earth is estimated at 140 000, yet perhaps only 10 % (approximately 14 000 named species) are known. Th ey make up a vast and yet largely untapped source of powerful new

Review Mushrooms: A Source of Immunomodulating and Antitumor Polysaccharides

The number of mushrooms on Earth is estimated at 1, 40,000 of which may be only 10% are known. Meanwhile, of those ~ 14,000 species tha t we known today, about 50% are considered to possess varying

Bioactives from Mushroom and Their Application

TLDR
It is very important to improve and optimize conditions for mycelial growth in vitro and create new strains by genetic modification in order to produce large amounts of those compounds of interest.

Screening of Mushrooms for Polysaccharides

TLDR
M Mushroom polysaccharides are well known for their antidiabetic, antitumor and hepatoprotective activities, and so are likely to be used in the preparation of novel drugs.

Higher Basidiomycetes Mushrooms as a Source Of Antioxidants

TLDR
In the last few years, there has been significant interest in the use of mushrooms and/or mushroom extracts as dietary supplements based on theories that they enhance immune function and promote health.

Compounds from wild mushrooms with antitumor potential.

TLDR
This work will review the compounds with antitumor potential identified so far in mushrooms, including low-molecular-weight (LMW, e.g. quinones, cerebrosides, isoflavones, catechols, amines, triacylglycerols, sesquiterpenes, steroids, organic germanium and selenium).

Fungal Mushrooms: A Natural Compound With Therapeutic Applications

TLDR
The safety and therapeutic effectiveness of the fungal mushrooms had shifted the interest of biotechnologists toward fungal nanobiotechnology as the drug delivery system due to the vast advantages of nanotechnology systems.

Recent Progress in Research on the Pharmacological Potential of Mushrooms and Prospects for Their Clinical Application

TLDR
This review discusses recent advances in research on the pharmacological potential of mushrooms and perspectives for their clinical application.
...

References

SHOWING 1-10 OF 138 REFERENCES

Mushrooms, tumors, and immunity.

TLDR
The antitumor mechanisms of several species of whole mushrooms as well as of polysaccharides isolated from Lentinus edodes, Schizophyllum commune, Grifola frondosa, and Sclerotinia sclerotiorum are mediated largely by T cells and macrophages, and the means by which they modulate the immune system and potentially exert tumor-inhibitory effects are reviewed.

Antitumor‐active substances from mushrooms

TLDR
In Japan three different polysaccharide antitumor agents have been isolated from the fruiting body, mycelium, and cultured medium, from three mushroom species.

The medicinal value of the mushroomGrifola

This review contains the most recent information on the various substances isolated and Identified in the maitake mushroomGrifola, their source and significance. The majority of the references

The use of mushroom glucans and proteoglycans in cancer treatment.

  • P. Kidd
  • Medicine, Biology
    Alternative medicine review : a journal of clinical therapeutic
  • 2000
TLDR
Two proteoglycans from Coriolus versicolor - PSK and PSP - have demonstrated the most promise and their extremely high tolerability, proven benefits to survival and quality of life, and compatibility with chemotherapy and radiation therapy makes them well suited for cancer management regimens.

Antitumor active protein-containing glycans from the Chinese mushroom songshan lingzhi, Ganoderma tsugae mycelium.

TLDR
A water-soluble polysaccharide, FI, extracted from the mycelium of Granoderma tsugae, was fractionated and purified by ion-exchange chromatography, gel filtration, and affinity chromatography for antitumor effects on Sarcoma 180 in mice.

Polysaccharides in fungi. XXIX. Structural features of two antitumor polysaccharides from the fruiting bodies of Armillariella tabescens.

TLDR
The results indicate that the major constituent of AT-HW (molecular weight, 105000), a heteroglycan, is composed primarily of beta-(1----6)-linked D-glucopyranosyl and D-galactopyranose residues, and contains their branched residues and terminal sugar residues.

Polysaccharides in Fungi. XXXIV. A polysaccharide from the fruiting bodies of Amanita muscaria and the antitumor activity of its carboxymethylated product.

TLDR
The results of chemical and spectroscopic investigations indicate that AM-APP is a linear (1 --> 3)-alpha-D-glucan with a molecular weigh estimated by gel chromatography of about 42000.

Antitumor activity of some polysaccharides isolated from a Chinese mushroom, "huangmo", the fruiting body of Hohenbuehelia serotina.

TLDR
Six fractions which showed relatively high activities were examined and were selected on the basis of the results of the antitumor activity test (the Sarcoma 180/mice, i.p. method).

Antitumor active polysaccharides from the Chinese mushroom Songshan lingzhi, the fruiting body of Ganoderma tsugae.

  • G. WangJ. Zhang J. Li
  • Medicine, Chemistry
    Bioscience, biotechnology, and biochemistry
  • 1993
TLDR
A systematic method of extraction, fractionation, and purification of polysaccharides from Songshan Lingzhi (Ganoderma tsugae) with antitumor activity was established, finding protein-containing (1-->3)-beta-D-glucans showing the strongest activity.

Fractionation and purification of the polysaccharides with marked antitumor activity, especially lentinan, from Lentinus edodes (Berk.) Sing. (an edible mushroom).

TLDR
The first two polysaccharide preparations have a strong antitumor effect; lentinan, especially, markedly inhibited the growth of Sarcoma 180 implanted s.c. in mice, inducing almost complete regression of tumors at doses of 1 mg/kg × 10 with no sign of toxicity.
...