Medicinal chemistry of A2A adenosine receptor antagonists.

  title={Medicinal chemistry of A2A adenosine receptor antagonists.},
  author={Barbara Cacciari and Giorgia Pastorin and Giampiero Spalluto},
  journal={Current topics in medicinal chemistry},
  volume={3 4},
Due to the clearly demonstrated receptor-receptor interaction between adenosine A(2A) and dopamine D(2) receptors in the basal ganglia, the discovery and development of potent and selective A(2A)adenosine receptor antagonists became, in the last ten years, an attractive field of research to discovery new drugs for the treatment of neurodegenerative disorders, such as Parkinsons disease. Different compounds have been deeply investigated as A(2A) adenosine receptor antagonists, which could be… CONTINUE READING