Medicinal chemical properties of successful central nervous system drugs

@article{Pajouhesh2005MedicinalCP,
  title={Medicinal chemical properties of successful central nervous system drugs},
  author={Hassan Pajouhesh and George R. Lenz},
  journal={NeuroRX},
  year={2005},
  volume={2},
  pages={541-553}
}
Fundamental physiochemical features of CNS drugs are related to their ability to penetrate the blood-brain barrier affinity and exhibit CNS activity. Factors relevant to the success of CNS drugs are reviewed. CNS drugs show values of molecular weight, lipophilicity, and hydrogen bond donor and acceptor that in general have a smaller range than general therapeutics. Pharmacokinetic properties can be manipulated by the medicinal chemist to a significant extent. The solubility, permeability… CONTINUE READING
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