• DOI:10.1211/0022357022304
Corpus ID: 73169309

Medicinal cannabis: is Δ9–tetrahydrocannabinol necessary for all its effects?

@article{Wilkinson2003MedicinalCI,
  title={Medicinal cannabis: is Δ9–tetrahydrocannabinol necessary for all its effects?},
  author={J. D. Wilkinson and Benjamin J. Whalley and D. Baker and G. Pryce and A. Constanti and S. Gibbons and Elizabeth Williamson},
  journal={Journal of Pharmacy and Pharmacology},
  year={2003},
  volume={55}
}

J. D. Wilkinson, Benjamin J. Whalley, +4 authors Elizabeth Williamson

Published 2003

Medicine

Journal of Pharmacy and Pharmacology

Cannabis is under clinical investigation to assess its potential for medicinal use, but the question arises as to whether there is any advantage in using cannabis extracts compared with isolated Δ9‐trans‐tetrahydrocannabinol (Δ9THC), the major psychoactive component. We have compared the effect of a standardized cannabis extract (SCE) with pure Δ9THC, at matched concentrations of Δ9THC, and also with a Δ9THC‐free extract (Δ9THC‐free SCE), using two cannabinoid‐sensitive models, a mouse model of… CONTINUE READING

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