Medicinal Mushrooms and Cancer Therapy: translating a traditional practice into Western medicine

@article{Sullivan2006MedicinalMA,
  title={Medicinal Mushrooms and Cancer Therapy: translating a traditional practice into Western medicine},
  author={Richard Sullivan and John E. Smith and Neil J. Rowan},
  journal={Perspectives in Biology and Medicine},
  year={2006},
  volume={49},
  pages={159 - 170}
}
Modern medical practice relies heavily on the use of highly purified pharmaceutical compounds whose purity can be easily assessed and whose pharmaceutical activity and toxicity show clear structure-function relationships. In contrast, many herbal medicines contain mixtures of natural compounds that have not undergone detailed chemical analyses and whose mechanism of action is not known. Traditional folk medicine and ethno-pharmacology coupled to bioprospecting have been an important source of… 

Figures from this paper

Bioactive metabolites from macrofungi: ethnopharmacology, biological activities and chemistry

This review compile the information on bioactive structure-elucidated metabolites from macrofungi discovered over the last decade and highlight their unique chemical diversity and potential benefits to novel drug discovery.

Biomedical effects of mushrooms with emphasis on pure compounds

M Mushroom compounds require testing against infectious diseases such as those caused by bacteria, because the current antibiotics are failing from resistances and the future is assured for medicinal mushrooms.

ROLE OF MUSHROOMS AS NUTRACEUTICAL AN OVERVIEW

The present topic, ‘Role of Mushrooms as ‘Nutraceutical’ has been chosen giving emphasis on the pharmaceutical properties of some edible mushrooms which can safely be used as Nutraceutical.

IMPORTANT HERBS IN TREATMENT OF CANCER

Cancer is a major public health burden in both developed and developing countries. Plant derived agents are being used for the treatment of cancer. Reservoir of bioactive compounds exists in many

ETHNOMEDICINAL PLANTS FOR CANCER THERAPY - A REVIEW

A detailed review of ethno medicinally important plants in cancer from Indian medicinal plants which will be useful to treat various types of cancer are revealed.

Botanicals used in complementary and alternative medicine treatment of cancer: clinical science and future perspectives

A number of botanicals have shown promise for cancer symptom management but need further study, and a limited number of multi-agent nutritional supplement approaches are being explored in clinical trials.

Recent Progress in Research on the Pharmacological Potential of Mushrooms and Prospects for Their Clinical Application

This review discusses recent advances in research on the pharmacological potential of mushrooms and perspectives for their clinical application.

A review of Anticancer Properties of Herbal Medicines

This paper aimed to investigate the medicinal plants which are endemic in many parts of the world and were used for the treatment of various cancers and appropriated ones that are used in cancer treatment as well as metabolites that are extracted from.

Evidence-based Materia Medica for Cancer Chemoprevention

This chapter highlights major molecular mechanisms in chemoprevention and summarizes the research on ten promising cancer preventive herbal products, including nine from TCM (Danshen, Danggui, Qianghuo, Huangqin, Zicao, Dasuan, LingZhi, Yunzhi, and Xianggu) and five from TIM (Triphala, Turmeric, Neem, Guggulu, and Sapthaparna).
...

References

SHOWING 1-10 OF 60 REFERENCES

Plant-derived anticancer agents.

  • J. Pezzuto
  • Biology, Medicine
    Biochemical pharmacology
  • 1997

Medicinal mushrooms as a source of antitumor and immunomodulating polysaccharides

  • S. Wasser
  • Biology, Medicine
    Applied Microbiology and Biotechnology
  • 2002
The present review analyzes the pecularities of polysaccharides derived from fruiting bodies and cultured mycelium in selected examples of medicinal mushrooms and concludes that high molecular weight glucans appear to be more effective than those of low molecular weight.

The use of mushroom glucans and proteoglycans in cancer treatment.

  • P. Kidd
  • Medicine, Biology
    Alternative medicine review : a journal of clinical therapeutic
  • 2000
Two proteoglycans from Coriolus versicolor - PSK and PSP - have demonstrated the most promise and their extremely high tolerability, proven benefits to survival and quality of life, and compatibility with chemotherapy and radiation therapy makes them well suited for cancer management regimens.

The New Face of Traditional Chinese Medicine

TOKYO-- This year, the U.S. Food and Drug Administration approved a phase II trial to test the efficacy of Kanglaite in treating non-small-cell lung cancer, making Kanglaite the first drug derived

Induction of apoptosis in human prostatic cancer cells with beta-glucan (Maitake mushroom polysaccharide).

A bioactive beta-glucan from the Maitake mushroom has a cytotoxic effect, presumably through oxidative stress, on prostatic cancer cells in vitro, leading to apoptosis.

Antitumor activity exhibited by orally administered extract from fruit body of Grifola frondosa (maitake).

D-fraction was found to potentiate the delayed-type hypersensitivity response which is associated with tumor growth suppression and indicates that stimulation of the immune response system triggered by the tumor-bearing state is activated by D- fraction.

Immunomodulation and anti-cancer activity of polysaccharide-protein complexes.

Polysaccharides or polysaccharide-protein complexes are considered as multi-cytokine inducers that are able to induce gene expression of vaious immunomodulatory cytokines and cytokine receptors and act as biological response modifiers.

Medicinal properties of substances occurring in higher basidiomycetes mushrooms: current perspectives (review).

Clinical intervention studies have demonstrated the therapeutic importance of correcting the hypercholesterolemia and the initial step in lowering cholesterol is a special diet low in fat and saturated fatty acids and rich in crude fibers.

Activity of Maitake D‐fraction to Inhibit Carcinogenesis and Metastasis

  • H. Nanba
  • Medicine
    Annals of the New York Academy of Sciences
  • 1995
Maitake mushroom (Grijola frondosa) has the strongest antitumor activity in tumor growth inhibition both when administered orally and intraperit0neal1y.

Clinical value of immunochemotherapy with OK-432 or PS-K for stomach cancer patients

A prospective clinical trial was undertaken in 121 patients with stomach cancer to compare immunochemotherapy with 5-fluorouracil and FT-207 combined with OK-432 or PS-K, immunostimulators, and plain
...