Medication-overuse headache and opioid-induced hyperalgesia: A review of mechanisms, a neuroimmune hypothesis and a novel approach to treatment

@article{Johnson2013MedicationoveruseHA,
  title={Medication-overuse headache and opioid-induced hyperalgesia: A review of mechanisms, a neuroimmune hypothesis and a novel approach to treatment},
  author={J. Johnson and M. Hutchinson and Desmond B. Williams and P. Rolan},
  journal={Cephalalgia},
  year={2013},
  volume={33},
  pages={52 - 64}
}
Introduction Patients with chronic headache who consume large amounts of analgesics are often encountered in clinical practice. Excessive intake of analgesics is now considered to be a cause, rather than simply a consequence, of frequent headaches, and as such the diagnosis “medication-overuse headache” (MOH) has been formulated. Despite the prevalence and clinical impact of MOH, the pathophysiology behind this disorder remains unclear and specific mechanism-based treatment options are lacking… Expand
The Evolution of Medication Overuse Headache: History, Pathophysiology and Clinical Update
TLDR
Results indicate that patients with medication overuse, who are treated with new medications, may not need to be detoxified in order to treat MOH, and it is likely that in the future MOH will be more readily diagnosed and treatment will result in better outcomes. Expand
Medication-overuse headache: a perspective review
TLDR
There is fertile ground for research in MOH epidemiology, pathophysiology, and neuroimaging and Randomized and long-term follow-up studies on MOH treatment protocols are needed. Expand
Headache of Analgesic Abuse as a Cause of New Pain Pathways Development
TLDR
This chapter focuses on an overall discussion of medication abuse as a novel pain pathway in headaches and its implications for the management of MOH. Expand
Too Much of a Good Thing: Medication Overuse Headache
TLDR
Medication overuse headache is frequently observed in the primary care setting, is one of the most common headaches seen in tertiary care headache clinics, and should be considered in any individual with chronic migraine. Expand
Medication Overuse Headache
TLDR
MOH can severely impact quality of life, so it is important to identify patients who are at risk of analgesic overuse and stop the offending drug(s), rescue therapy for withdrawal symptoms and preventative therapy. Expand
Medication overuse and chronic migraine: a critical review according to clinical pharmacology
TLDR
This narrative review describes how to try to prevent the development of MOH and how to manage it once it has appeared, and detects disease biomarkers and predictive factors for drug response that allow for personalized treatment when migraine is still episodic and make analgesic overuse pointless. Expand
Neuroimaging Findings in Patients with Medication Overuse Headache
TLDR
Changes of brain function at similar areas have been revealed by positron emission tomography and functional magnetic resonance imaging studies, and orbitofrontal cortex is of interest, as implicated in psychological studies of MOH. Expand
Hiperalgesia asociada al tratamiento con opioides
TLDR
Recent advances in the understanding of the underlying mechanisms, clinical studies and available treatment strategies for opioid induced hyperalgesia are reviewed. Expand
Clinical Aspects of Medication Overuse Headaches
Medication overuse headache (MOH) is a subset of chronic daily headache, occurring from overuse of 1 or more classes of migraine abortive medication. Acetaminophen, combination analgesics (caffeineExpand
Medication Overuse Headache: The Reason of Headache That Common and Preventable.
TLDR
The primary prevention with education of the patients as well as early diagnosis and treatment of MOH will reduce its increasing financial burden on both patients and countries and meticulous and multifactorial evaluation of the disease besides the diagnosis and Treatment of the comorbid diseases will reduce the risk of recurrences. Expand
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References

SHOWING 1-10 OF 181 REFERENCES
Clinical features, pathophysiology, and treatment of medication-overuse headache
TLDR
As MOH can severely affect the quality of life of patients, it needs to be recognised early to enable appropriate treatment to be initiated and there is no clear evidence on which method of withdrawal therapy is the most efficacious. Expand
Pathophysiology of medication overuse headache: Insights and hypotheses from preclinical studies
TLDR
Examination of the link between several mechanisms that have been linked to migraine headache and a potential role in MOH finds that cortical spreading depression, associated with migraine development, is increased in frequency with prolonged use of topiramate or paracetamol. Expand
Opioid-Induced Hyperalgesia: Clinically Relevant or Extraneous Research Phenomenon?
TLDR
A nonexhaustive, brief review of the recent literature on opioid-induced hyperalgesia (OIH) will be reviewed in terms of preclinical and clinical evidence for and against its existence; recommendations for clinical evaluation and intervention also will be discussed. Expand
Pharmacological Treatment of Opioid-Induced Hyperalgesia: A Review of the Evidence
TLDR
The objective of this study was to review the preliminary evidence related to the treatment and management of opioid-induced hyperalgesia and to set the stage for an eventual meta-analysis. Expand
Opioid-induced Hyperalgesia in Humans: Molecular Mechanisms and Clinical Considerations
TLDR
Clinicians should suspect expression of OIH when opioid treatment effect seems to wane in the absence of disease progression, particularly if found in the context of unexplained pain reports or diffuse allodynia unassociated with the pain as previously observed. Expand
Medication-overuse headache: a worldwide problem
TLDR
The new international classification of headache disorders has now incorporated additional criteria and new headache entities that will facilitate the diagnosis of MOH. Expand
Medication Overuse Headache in Scandinavia
TLDR
The use of simple analgesics and combination drugs has steadily increased in Denmark with a 12% increase over the last 5 years and the paradox that painkillers are usually effective for the treatment of the individual headache attack, whereas frequent intake of painkillers may aggravate the headache, and act as a pain trigger, is still unexplained. Expand
Medication-overuse headache: where are we now?
TLDR
Recent data provide better insight into pathophysiology of medication-overuse headache and the necessity of establishing a predictive model for early recognition of patients at high risk to intervene early and avoid development of chronic headache is demonstrated. Expand
Review: Drug and nondrug treatment in tension-type headache
  • L. Bendtsen
  • Medicine
  • Therapeutic advances in neurological disorders
  • 2009
TLDR
Treatment of frequent TTH is often difficult and multidisciplinary treatment strategies can be useful, and the development of specific nonpharmacological and pharmacological managements for TTH with higher efficacy and fewer side effects is urgently needed. Expand
Pathophysiology of Medication-overuse Headache: Implications from Animal Studies
TLDR
Derangement in the central 5-HT–dependent modulating system as a result of chronic medication use may underlie the chronification of headache as observed in patients with medication-overuse headache. Expand
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