Medication-overuse headache: a worldwide problem

  title={Medication-overuse headache: a worldwide problem},
  author={Hans Christoph Diener and Volker Limmroth},
  journal={The Lancet Neurology},

Practical management of medication-overuse headache.

Epidemiological studies suggest that medication-overuse as defined by the International Headache Society is extremely common in patients with chronic daily headache. If all medication-overuse

Medication-overuse headache: epidemiology, diagnosis and treatment

It is suggested that the first step in the treatment of MOH should be carried out in general practice and should focus primarily on detoxification, thus freeing resources for referral of more complicated cases to headache clinics and neurologists.

Chronic headaches and medication overuse

Patients with medication overuse headache had migraine as primary headache, and treatment of MOH is poorly evidence based and mostly relies on clinical experience and belief.

Medication-overuse headache: similarities with drug addiction.

Medication-Overuse Headache in Japan

Japan seems to have a similar prevalence of medication overuse headache, but the drugs which cause MOH may vary from country to country, since their availabilities in the market differ, and cultural factors greatly affect people’s attitudes.

Medication-overuse headache: risk factors, pathophysiology and management

In all patients with MOH, relapse rates can be reduced by patient education and care in the follow-up period, and the success rate of treatment is around 50–70%, although patients whose MOH is associated with opioid overuse have higher relapse rates.

What future for treatment of chronic migraine with medication overuse?

The clinical experience performed at the Headache Unit, the necessity of withdrawal, different treatment schedules, and different treatment strategies of the center were discussed.

Treatment of chronic migraine with medication overuse: is drug withdrawal crucial?

The necessity of withdrawal performed by different treatment schedules, outcomes, and the long-term durability of treatment are discussed.

Headache of Analgesic Abuse as a Cause of New Pain Pathways Development

This chapter focuses on an overall discussion of medication abuse as a novel pain pathway in headaches and its implications for the management of MOH.



Features of medication overuse headache following overuse of different acute headache drugs

Although patients overusing ergots and analgesics typically had a daily tension-type headache, patients with triptan-induced MOH were more likely to describe a (daily) migrainelike headache or an increase in migraine frequency.

Analgesic Overuse Is A Cause of Chronic Daily Headache

The development of headache consequent to drug overuse was first proposed over 60 years ago, when Dreisbach suggested that caffeine could cause both chemical dependence and withdrawal headaches upon cessation.

Drug Abuse in Chronic Headache: A Clinico-Epidemiologic Study

The investigation suggests that all instant-relief drugs can sustain and possibly initiate a chronic headache.

Clinical and Epidemiological Observations on Drug Abuse in Headache Patients

The chances of a successful outcome in this field are as limited as in the past because treatment is restricted to the use of either ergotamine derivatives or various combination products, or nonsteroidal anti-inflammatory drugs which are widely used in many other painful conditions.

Rates and predictors for relapse in medication overuse headache: A 1-year prospective study

The authors prospectively studied 98 patients with medication overuse headache and found the 1-year relapse rate was lower for patients with migraine compared with tension-type headache and combination of migraine and tension- type headache than for patients overusing triptans or ergots.

Prednisone as Initial Treatment of Analgesic-Induced Daily Headache

It is demonstrated that it is possible to detoxify patients suffering from rebound headaches, using oral prednisone during the first days of withdrawal, in an out-patient setting.

Successful Withdrawal From Analgesic Abuse in a Group of Youngsters With Chronic Daily Headache

Successful withdrawal from the offending analgesics was achieved without hospitalization or significant interference with daily life and with complete disappearance of the induced chronic daily headache in 25 of 26 patients.

Drug-Induced Headache: Long-Term Follow-Up of Withdrawal Therapy and Persistence of Drug Misuse

The data show a higher relapse rate than previously assumed and that certain substance groups bear aHigher relapse risk.

Analgesic-induced chronic headache: long-term results of withdrawal therapy

Migraine prophylaxis through beta-blocking agents and calcium channel antagonists was more efficient after drug-withdrawal therapy and patients who originally suffered from migraine, superimposed on the daily headache, also experienced a significant improvement in the frequency of the migraines and their intensity.