Medication adherence: emerging use of technology

  title={Medication adherence: emerging use of technology},
  author={Bradi B. Granger and Hayden Barry Bosworth},
  journal={Current Opinion in Cardiology},
Purpose of review Adherence to proven, effective medications remains low, resulting in high rates of clinical complications, hospital readmissions, and death. The use of technology to identify patients at risk and to target interventions for poor adherence has increased. This review focuses on research that tests these emerging technologies and evaluates the effect of technology-based adherence interventions on cardiovascular outcomes. Recent findings Recent studies have evaluated technology… 
Electronic Health Record–Based Strategy to Promote Medication Adherence Among Patients With Diabetes: Longitudinal Observational Study
It is suggested that the EMC2 strategy can be reliably implemented and delivered to patients, with high levels of satisfaction, and future trials are needed to evaluate its effectiveness to promote adherence and safety.
Technology-based interventions to improve adherence to antihypertensive medications – An evidence-based review
RCTs on technological interventions to improve adherence and those showing significant effect are rare and some of the interventions show potential to be applied to other populations, especially if targeted at patients with poor adherence at baseline.
Electronic medication packaging devices and medication adherence: a systematic review.
Systematic review of peer-reviewed studies testing the effectiveness of EMP systems in the MEDLINE, EMBASE, PsycINFO, CINAHL, International Pharmaceutical Abstracts, and Sociological Abstracts databases finds devices integrated into the care delivery system and designed to record dosing events are most frequently associated with improved adherence, compared with other devices.
Real-world impact of reminder packaging on antihypertensive treatment adherence and persistence
This real-world assessment of differences in adherence and persistence rates demonstrated that patients receiving RP were more adherent and persistent with their treatment regimens.
How can innovative uses of technology be harnessed to improve medication adherence?
  • H. Bosworth
  • Medicine, Political Science
    Expert review of pharmacoeconomics & outcomes research
  • 2012
There has been growing interest in leveraging technology, whether it be mHealth, interactive voice response (IVR) or electronic medical records, to improve medication adherence.
Advances in Patient Adherence to Medical Treatment Regimens: The Emerging Role of Technology in Adherence Monitoring and Management: Technological Advances in Patient Adherence
Recent advances in adherence monitoring and management including m-health, home telemonitoring systems, web-based support (i.e., self-management websites and virtual support groups), and patient portals and personal health records are reviewed before concluding with a brief account of some exciting new technologies under development in the context of patient adherence.
A meta-analysis of the use of electronic reminders for patient adherence to medication in chronic disease care
The meta-analysis showed that the use of electronic reminders was associated with a significant, yet small, improvement in patient adherence to medication (pooled Cohen’s d=0.29, 95% confidence interval 0.18, 0.41).
Evidence of poor adherence to secondary prevention after acute coronary syndromes: possible remedies through the application of new technologies
Using technology to improve adherence in ACS is an emerging strategy and has the potential to address many of the above factors—computer-based education and mobile phone reminders are among the interventions trialled and appear to improve adhere in patients with ACS.


Effect of a Pharmacy-Based Health Literacy Intervention and Patient Characteristics on Medication Refill Adherence in an Urban Health System
Implementation of a 3-part intervention—automated telephone reminders, picture prescription card, and pharmacist communication skills training—did not significantly improve refill adherence among inner-city patients.
Interventions to improve medication‐adherence after transplantation: a systematic review
No single intervention proved to be superior at increasing medication‐adherence in organ transplantation, but a combination of interventions in a team approach for the chronic disease management of organ transplant patients may be effective in a long‐term perspective.
Medication Adherence: A Review of the Literature and Implications for Clinical Practice
Based on a comprehensive literature review, the authors recommend the following strategies for addressing adherence problems: focus on strengthening the therapeutic alliance; devote time in treatment specifically to address medication adherence; assess patients' motivation to take prescribed medications; and identify and address potential barriers to treatment adherence.
Medication non-adherence--exploring the conceptual mire.
The underlying philosophical attributes of adherence and the interchangeable concepts of compliance and concordance are explored, with the implications of the meanings attributed to these concepts for nursing practice and research considered.
Improving medication adherence in diabetes type 2 patients through Real Time Medication Monitoring: a Randomised Controlled Trial to evaluate the effect of monitoring patients' medication use combined with short message service (SMS) reminders
If RTMM proves to be effective, it can be considered for use in various patient populations to support patients with their medication use and improve their adherence.
A Pharmaceutical Care Program to Improve Adherence to Statin Therapy: A Randomized Controlled Trial
These results demonstrate the feasibility and effectiveness of a community pharmacy–based pharmaceutical care program to improve medication adherence in new users of statins and can be applied easily to a larger population and have a large impact.
The modeled lifetime cost-effectiveness of published adherence-improving interventions for antihypertensive and lipid-lowering medications.
Of published interventions shown to improve adherence, reminders and educational materials, and a pharmacist/nurse management program, appear to be cost-effective and should be considered before other interventions.
The impact of an electronic monitoring and reminder device on patient compliance with antihypertensive therapy: a randomized controlled trial
The Helping Hand reminder device was most suitable if used for newly diagnosed hypertensive patients, when it improved compliance by 6%, but with less forgiving medications the device might make a significant difference.
Electronic monitoring of patient adherence to oral antihypertensive medical treatment: a systematic review
Electronic monitoring of patient adherence to self-administered oral antihypertensive medications seems to have the potential to significantly improve blood pressure control as well and should be used more widely.
The Team Education and Adherence Monitoring (TEAM) trial: pharmacy interventions to improve hypertension control in blacks.
The Team Education and Adherence Monitoring (TEAM) Trial is a randomized controlled trial testing a multistep intervention for improving adherence monitoring and intervention in 28 corporately owned community pharmacies.