Medication Overuse Headache: Withdrawal and Prophylactic Therapeutic Regimen

@article{Trucco2010MedicationOH,
  title={Medication Overuse Headache: Withdrawal and Prophylactic Therapeutic Regimen},
  author={Marco Trucco and Piero Meineri and Luigi Ruiz and Maurizio Gionco},
  journal={Headache: The Journal of Head and Face Pain},
  year={2010},
  volume={50}
}
(Headache 2010;50:989‐997) 
Treatment of medication overuse headache – guideline of the EFNS headache panel
TLDR
Treatment is based on education, withdrawal treatment (detoxification), and prophylactic treatment, which also includes management of withdrawal headache.
The Many Faces of Medication‐Overuse Headache in Clinical Practice
TLDR
The purpose of this review is to provide an overview of the literature on the management of MOH, and to highlight important considerations in the clinical evaluation of the MOH patient.
Celecoxib vs Prednisone for the Treatment of Withdrawal Headache in Patients With Medication Overuse Headache: A Randomized, Double‐Blind Clinical Trial
TLDR
To compare the efficacy of celecoxib for treatment of withdrawal headache vs prednisone in patients with medication overuse headache, a comparison study is conducted with real-time data over a 12-week period.
European Academy of Neurology guideline on the management of medication‐overuse headache
The frequent use of medication to treat migraine attacks can lead to an increase in migraine frequency and is called medication‐overuse headache (MOH).
Preventive migraine treatment with eptinezumab reduced acute headache medication and headache frequency to below diagnostic thresholds in patients with chronic migraine and medication‐overuse headache
This post hoc analysis in patients medically diagnosed with chronic migraine (CM) and medication‐overuse headache (MOH) evaluated reductions in the use of acute headache medication (AHM) and
Complete withdrawal is the most feasible treatment for medication‐overuse headache: A randomized controlled open‐label trial
Complete stop of acute medication and/or migraine medication for treatment of medication‐overuse headache (MOH) has previously been reported more effective in reducing headache days and migraine days
Management of migraine headache: An overview of current practice
  • Clay Shugart
  • Medicine, Psychology
    JAAPA : official journal of the American Academy of Physician Assistants
  • 2012
TLDR
Using both pharmacologic and nonpharmacologic therapies for acute treatment and as preventive therapy can help patients with migraine to avoid debilitating symptoms.
Medication Overuse Headache
TLDR
MOH can severely impact quality of life, so it is important to identify patients who are at risk of analgesic overuse and stop the offending drug(s), rescue therapy for withdrawal symptoms and preventative therapy.
Complete detoxification is the most effective treatment of medication-overuse headache: A randomized controlled open-label trial
TLDR
Detoxification without analgesics or acute migraine-medication was the most effective program and both detoxification programs were very effective.
Effect of selective serotonin reuptake inhibitor treatment on the prognosis of patients with medication overuse headache
TLDR
Selective serotonin reuptake inhibitor can increase the therapeutic effect in medication overuse headache withdrawal therapy and can reduce the risk of relapse.
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References

SHOWING 1-10 OF 22 REFERENCES
Prednisone vs. Placebo in Withdrawal Therapy Following Medication Overuse Headache
TLDR
The results show that prednisone might be effective in the treatment of medication withdrawal headache.
Management of Medication Overuse Headache: 1-Year Randomized Multicentre Open-Label Trial
TLDR
Early introduction of preventive treatment without a previous detoxification programme reduced total headache suffering more effectively compared with abrupt withdrawal.
Discontinuation of Medication Overuse in Headache Patients: Recovery of Therapeutic Responsiveness
TLDR
It is found that after 1 year, those who had stopped their overuse had a reduction in the number of headache days of the order of 73.7%, vs. just 17.2% in those who continued to overuse.
Headaches Associated With Chronic Use of Analgesics: A Therapeutic Approach
TLDR
It is shown that within the group of relapsing patients the outpatients relapsed to analgesic intake more than the day hospital‐treated patients (P<0.001), and there were no differences in reduction of mean values of the Headache Index or daily drug intake with respect to the two treatments.
Epidemiology of Chronic Daily Headache in the General Population
TLDR
This study analyzes the prevalence of the different types of chronic daily headache in an unselected population to find out the actual prevalence of transformed migraine.
Out-Patient Detoxification in Chronic Migraine: Comparison of Strategies
TLDR
It is concluded that CM patients with moderate overuse of SM other than opioids may be detoxified on an out-patient basis regardless of the strategy adopted with regard to the use of regular drugs during the initial days of withdrawal, but prednisone and naratriptan may be useful for reducing withdrawal symptoms and rescue medication consumption.
Prednisolone does not reduce withdrawal headache
TLDR
Prednisolone has no effect on withdrawal headache in unselected patients with chronic daily headache and medication overuse.
Probable medication-overuse headache
TLDR
The benefit of withdrawal in already established medication overuse is demonstrated and the existence of medication-overuse headache as a clinical entity is supported.
Drug-Induced Headache: Long-Term Results of Stationary Versus Ambulatory Withdrawal Therapy
TLDR
The data suggest that neither the method of withdrawal therapy nor the kind of analgesic and other antimigraine drugs has a major impact on the long-term result after successful withdrawal therapy in drug-induced headache.
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