Medication Overuse Headache: History, Features, Prevention and Management Strategies

@article{Saper2013MedicationOH,
  title={Medication Overuse Headache: History, Features, Prevention and Management Strategies},
  author={J. Saper and A. N. Da Silva},
  journal={CNS Drugs},
  year={2013},
  volume={27},
  pages={867-877}
}
Medication overuse headache (MOH) is a daily, or almost daily, headache form that arises from overuse of one or more classes of migraine-abortive or analgesic medication. The main classes of drugs that cause MOH are opioids, butalbital-containing mixed analgesics, triptans, ergotamine tartrate derivatives, simple analgesics (except for plain aspirin), and perhaps non-steroidal anti-inflammatory drugs. MOH can be debilitating and results from biochemical and functional brain changes induced by… Expand
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Citation Type

Citation Type

Medication Overuse Headache
TLDR
MOH can severely impact quality of life, so it is important to identify patients who are at risk of analgesic overuse and stop the offending drug(s), rescue therapy for withdrawal symptoms and preventative therapy. Expand
Pathophysiology, prevention, and treatment of medication overuse headache
Regular or frequent use of analgesics and acute antimigraine drugs can increase the frequency of headache, and induce the transition from episodic to chronic headache or medication overuse headache.… Expand
Medication overuse headache: an overview of clinical aspects, mechanisms, and treatments
TLDR
This review aims at presenting MOH clinical features, pathophysiology insights, and recent knowledge and guidance regarding treatments as well as emerging treatments as monoclonal antibodies to migraine that may result in better adherence and tolerability profiles aswell as outcomes. Expand
Medication-overuse Headache
Medication-overuse headache (MOH) is a common neurologic disorder with enormous disability and suffering and plays a significant role in the transformation from episodic to chronic headache… Expand
Medication overuse and chronic migraine: a critical review according to clinical pharmacology
TLDR
This narrative review describes how to try to prevent the development of MOH and how to manage it once it has appeared, and detects disease biomarkers and predictive factors for drug response that allow for personalized treatment when migraine is still episodic and make analgesic overuse pointless. Expand
Neuroimaging Findings in Patients with Medication Overuse Headache
TLDR
Changes of brain function at similar areas have been revealed by positron emission tomography and functional magnetic resonance imaging studies, and orbitofrontal cortex is of interest, as implicated in psychological studies of MOH. Expand
Polypharmacy Among Headache Patients: A Cross-Sectional Study
TLDR
Patients with primary headaches, mainly young adults, are exposed to high polypharmacy, comparable to that of the elderly, because increased numbers of drugs increase the risk of adverse reactions, the many medications concomitantly taken by primary headache sufferers should be frequently reviewed. Expand
Prescription pain medications and chronic headache in Denmark: implications for preventing medication overuse
TLDR
High prevalence of opioid use among people with CH may be due to inappropriate headache treatment or development of MOH among those treated for other pain conditions, suggesting that migraine may be under-recognized and inappropriately treated, leading to overuse of other medications. Expand
Inpatient Management of Migraine.
TLDR
Inpatient treatment is indicated for migraine refractory to multiple outpatient treatments, with intractable nausea or vomiting, need for detoxification from medication overuse (such as opioids and barbiturates), and significant medical and psychiatric disease. Expand
Effects of fremanezumab on the use of acute headache medication and associated symptoms of migraine in patients with episodic migraine
TLDR
Fremanezumab reduced the need for acute headache medications, including migraine-specific medications, while treating migraine-associated symptoms in patients with episodic migraine. Expand
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References

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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
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TLDR
MIH is an underrecognized and difficult condition affecting headache-prone patients and it appears that complete withdrawal of the medications being overused is required for favorable long-term results. Expand
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