Medication Development of Ibogaine as a Pharmacotherapy for Drug Dependence a

@article{Mash1998MedicationDO,
  title={Medication Development of Ibogaine as a Pharmacotherapy for Drug Dependence a},
  author={Deborah C. Mash and Craig A. Kovera and Billy E. Buck and M D Norenberg and Paul Shapshak and William Lee Hearn and Juan R. Sanchez-Ramos},
  journal={Annals of the New York Academy of Sciences},
  year={1998},
  volume={844}
}
ABSTRACT: The potential for deriving new psychotherapeutic medications from natural sources has led to renewed interest in rain forest plants as a source of lead compounds for the development of antiaddiction medications. Ibogaine is an indole alkaloid found in the roots of Tabernanthe iboga (Apocynaceae family), a rain forest shrub that is native to equatorial Africa. Ibogaine is used by indigenous peoples in low doses to combat fatigue, hunger and in higher doses as a sacrament in religious… 
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Results may relate to observations of persistent QT prolongation and cardiac arrhythmia at delayed intervals of days following ibogaine ingestion, and suggest that the iboga alkaloids might provide an informative paradigm for investigation of the structural biology of the hERG channel.
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