Medication Development of Ibogaine as a Pharmacotherapy for Drug Dependence a

  title={Medication Development of Ibogaine as a Pharmacotherapy for Drug Dependence a},
  author={Deborah C. Mash and Craig A. Kovera and Billy E. Buck and M D Norenberg and Paul Shapshak and William Lee Hearn and Juan R. Sanchez-Ramos},
  journal={Annals of the New York Academy of Sciences},
ABSTRACT: The potential for deriving new psychotherapeutic medications from natural sources has led to renewed interest in rain forest plants as a source of lead compounds for the development of antiaddiction medications. Ibogaine is an indole alkaloid found in the roots of Tabernanthe iboga (Apocynaceae family), a rain forest shrub that is native to equatorial Africa. Ibogaine is used by indigenous peoples in low doses to combat fatigue, hunger and in higher doses as a sacrament in religious… 

Combating Substance Abuse with Ibogaine: Pre- and Posttreatment Recommendations and an Example of Successive Model Fitting Analyses

A number of theory-driven, pretreatment and posttreatment recommendations that have good potential for enhancing ibogaine's effectiveness are suggested and a minimum set of patient- and treatment-related variables be included in all ibogane publications involving human participants.

Ibogaine Detoxification Transitions Opioid and Cocaine Abusers Between Dependence and Abstinence: Clinical Observations and Treatment Outcomes

It is reported here that ibogaine therapy administered in a safe dose range diminishes opioid withdrawal symptoms and reduces drug cravings and product development of single oral dose administration of Ibogaine for the treatment of opioid withdrawal during medically supervised detoxification to transition drug dependent individuals to abstinence is supported.

Safety of ibogaine administration in detoxification of opioid dependent individuals: a descriptive open-label observational study.

This open‐label observational study found that ibogaine treatment of patients with opioid use disorder can induce a clinically relevant but reversible QTc prolongation, bradycardia, and severe ataxia.

Ibogaine offers an alternative approach for treating opiate addiction

Ibogaine is a naturally occurring indole alkaloid that may be an effective alternative form of treatment for individuals struggling with opiate addiction and/or withdrawal and is found that iboga alkaloids such as ibogaine are effective at reducing morphine self-administration in rats.

hERG Blockade by Iboga Alkaloids

Results may relate to observations of persistent QT prolongation and cardiac arrhythmia at delayed intervals of days following ibogaine ingestion, and suggest that the iboga alkaloids might provide an informative paradigm for investigation of the structural biology of the hERG channel.

Noribogaine (12‐Hydroxyibogamine): A Biologically Active Metabolite of the Antiaddictive Drug Ibogaine

The present data demonstrate that NORIBO is biologically active and undoubtedly contributes to the in vivo pharmacological profile of IBO in rats, and appears less likely to produce the adverse effects associated with IBO (i.e., tremors and stress‐axis activation), suggesting that the metabolite may be a safer alternative for medication development.