Medical management of thyroid dysfunction in pregnancy and the postpartum

@article{Okosieme2008MedicalMO,
  title={Medical management of thyroid dysfunction in pregnancy and the postpartum},
  author={O. Okosieme and H. Marx and J. Lazarus},
  journal={Expert Opinion on Pharmacotherapy},
  year={2008},
  volume={9},
  pages={2281 - 2293}
}
Background: Uncontrolled thyroid dysfunction in pregnancy is associated with adverse fetal and maternal outcomes. Objectives: To review relevant literature and developments in the medical management of thyroid dysfunction in pregnancy. Results: Hyperthyroidism in pregnancy requires careful control of maternal disease whilst avoiding fetal hypothyroidism. Propylthiouracil is the preferred antithyroid drug in pregnancy although thiamazole can be used where propylthiouracil is unavailable… Expand
25 Citations
Thyroid dysfunction in pregnancy: optimizing fetal and maternal outcomes
TLDR
This special report summarizes best practice in the management of thyroid dysfunction in pregnancy and states that a balance must be maintained between the control of maternal disease and the requirements of the developing fetus. Expand
Antenatal Thyroid Disease and Pharmacotherapy in Pregnancy
TLDR
This chapter is a review of thyroid physiology in pregnancy and the diagnosis, etiologies, pharmacotherapeutic management and surveillance of thyroid disease during pregnancy. Expand
Thyroid hormone dysfunction during pregnancy: A review
TLDR
The thyroid function changes occurring during pregnancy, the different disorders with their maternal and fetal implications, the laboratory diagnosis and the best ways of management of these conditions are assessed. Expand
Pregnancy and Hypothyroidism
TLDR
The most important implication of SCH is high likelihood of progression to clinical hypothyroidism during pregnancy and these patients needs thyroxine replacement during pregnancy to reduce adverse fetal outcomes. Expand
Thyroid Disease During Pregnancy
TLDR
The impact of thyroid dysfunction on infertility, miscarriage, thyroid nodules, and thyroid cancer during pregnancy is illuminated. Expand
Preconception thyroid-stimulating hormone and pregnancy outcomes in women with hypothyroidism.
TLDR
The majority of women with hypothyroidism do not achieve the recommended preconception and early gestation serum thyroid-stimulating hormone (TSH) level of <2.5 mU/L, and a TSH level above this threshold was not associated with adverse fetal and maternal outcomes. Expand
Effect of Preeclampsia on Ultrastructure of Thyroid Gland, Hepatic Type 1 Iodothyronine Deiodinase, and Thyroid Hormone Levels in Rats
TLDR
Findings indicated that preeclampsia could disrupt synthesis, secretion, and metabolism function of thyroid hormones by damaging thyroid follicular cells and interfering Dio1 expression. Expand
TSH levels and risk of miscarriage in women on long-term levothyroxine: a community-based study.
TLDR
The majority of levothyroxine-treated women have early gestational TSH levels above the recommended targets with a strong risk of miscarriage at levels exceeding 4.5 mU/L, and there is an urgent need to improve the adequacy of thyroid hormone replacement in early pregnancy. Expand
Therapy of endocrine disease: Impact of iodine supplementation in mild-to-moderate iodine deficiency: systematic review and meta-analysis.
TLDR
Iodine supplementation improves some maternal thyroid indices and may benefit aspects of cognitive function in school-age children, even in marginally iodine-deficient areas. Expand
Levothyroxine to increase live births in euthyroid women with thyroid antibodies trying to conceive: the TABLET RCT
TLDR
Levothyroxine therapy in a dose of 50 µg per day does not improve live birth rate in euthyroid women with thyroid peroxidase antibodies, and there is no association with clinical outcome. Expand
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