Medical management of benign prostatic hyperplasia: Results from a population-based study.


INTRODUCTION In men with bothersome lower urinary tract symptoms (LUTS), medical treatment usually represents the first line. We examined the patterns of medical management of benign prostatic hyperplasia (BPH) in the Montreal metropolitan area, within the context of a case control study focusing on incident prostate cancer. METHODS Cases were 1933 men with incident prostate cancer. Population controls included 1994 age-matched men. In-person interviews collected sociodemographic characteristics and medical history, including BPH diagnosis, its duration, and type of medical treatment received. Baseline characteristics were compared by the chi-square likelihood test for categorical variables and by the students t-test for continuously coded variables. RESULTS Overall, 1120 participants had history of BPH; of those 53.7% received medical treatment for BPH. Individuals with medically treated BPH, compared to individuals with medically untreated BPH, were older at index date [mean: 66.9 vs. 64.9 years, p<0.001)] and at diagnosis of BPH [mean: 62.3 vs. 60.3 years, p<0.001]. They also had a longer duration of BPH-history [mean: 4.7 vs. 4.0 years, p=0.02]. Regarding medical treatment, mono-therapy was more often used than combination therapy [87.6% vs. 12.4%, p<0.001]. Alpha-blockers (69.9%) were most commonly used as monotherapy, followed by 5alpha-reductase inhibitors (5ARIs) (26.6%). Alpha-blockers plus 5ARIs were the most common combination therapy (97.3%). CONCLUSIONS Despite evidence from randomized, controlled trials for better efficacy with use of combination therapy, monotherapy consisting of alpha-blockers or 5ARI, in that order, is most frequently used. Additionally, 5ARI use was more common than previously reported (27% vs. 15%).

DOI: 10.5489/cuaj.3058

Cite this paper

@article{Bishr2016MedicalMO, title={Medical management of benign prostatic hyperplasia: Results from a population-based study.}, author={Mohamed Bishr and Katharina Boehm and Vincent Trudeau and Zhe Tian and Paolo Dell'oglio and Jonas Schiffmann and Claudio Jeldres and Maxine Sun and Sharokh F. Shariat and Markus Graefen and Fred Saad and Pierre I. Karakiewicz}, journal={Canadian Urological Association journal = Journal de l'Association des urologues du Canada}, year={2016}, volume={10 1-2}, pages={55-9} }