Medical genetics: A marker for Stevens–Johnson syndrome

@article{Chung2004MedicalGA,
  title={Medical genetics: A marker for Stevens–Johnson syndrome},
  author={Wen-Hung Chung and Shuen-Iu Hung and H S Hong and Mo-Song Hsih and Licheng Yang and H. C. Ho and Jer-Yuarn Wu and Yuan-Tsong Chen},
  journal={Nature},
  year={2004},
  volume={428},
  pages={486-486}
}
Stevens–Johnson syndrome and the related disease toxic epidermal necrolysis are life-threatening reactions of the skin to particular types of medication. Here we show that there is a strong association in Han Chinese between a genetic marker, the human leukocyte antigen HLA–B*1502, and Stevens–Johnson syndrome induced by carbamazepine, a drug commonly prescribed for the treatment of seizures. It should be possible to exploit this association in a highly reliable test to predict severe adverse… 
A Genetic Marker for Stevens-Johnson Syndrome
TLDR
Genetic analyses in 44 patients who developed SJS in response to the antiseizure drug carbamazepine, and 101 patients who used CBZ without developing SJS, suggest individuals predisposed to develop SJS when exposed to specific agents are identified.
Stevens-Johnson syndrome and toxic epidermal necrolysis: an update on pharmacogenetics studies in drug-induced severe skin reaction.
TLDR
Recent progresses in the Pharmacogenetics studies related to Stevens-Johnson syndrome/toxic epidermal necrolysis are summarized reporting the major genetic factors identified in the last years as associated with the disease and highlighting the use of some of these genomic variants in the clinical practice.
Defining Regional Differences in Drug‐Induced Stevens–Johnson Syndrome/Toxic Epidermal Necrolysis: A Tool to Improve Drug Safety?
TLDR
Regional differences exist in the epidemiology of immunologically mediated adverse drug reactions, such as Stevens– Johnson syndrome/toxic epidermal necrolysis, but also in the way individual drugs are labeled, clues to the key drivers of these reactions, which are human leukocyte antigen (HLA) class I alleles.
A marker for Stevens-Johnson syndrome …: ethnicity matters
TLDR
Preliminary results from a European study of 12 carbamazepine-induced SJS/TEN cases (RegiSCAR) show that although the HLA region may contain important genes for SJS, the Hla-B*1502 allele is not a universal marker for this disease and that ethnicity matters.
The association of HLA B*15:02 allele and Stevens–Johnson syndrome/toxic epidermal necrolysis induced by aromatic anticonvulsant drugs in a South Indian population
  • K. Devi
  • Medicine
    International journal of dermatology
  • 2018
The presence of HLA‐B*15:02 allele is considered a risk factor for development of Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) in patients taking aromatic anticonvulsant drugs like
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TLDR
Finding a strong genetic association between a particular human leukocyte antigen (HLA)-B allele and the reaction to a specific drug provides evidence that the pathogenesis of the severe cutaneous adverse drug reactions involves major histocompatibility complex-restricted presentation of a drug or its metabolites for T-cell activation.
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TLDR
A multivariate genetic analysis method is used for the first time to handle the heterogeneity of clinical presentation, drug etiology, ethnicity and gender in these adverse events of Stevens-Johnson syndrome and toxic epidermal necrolysis.
Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: Associations, Outcomes, and Pathobiology-Thirty Years of Progress but Still Much to Be Done.
Although rare, Stevens-Johnson syndrome and toxic epidermal necrolysis remain among the most devastating of acute conditions involving the skin. In the past 30 years, tremendous progress has been
Medicolegal Consequences of Death due to Stevens Johnson Syndrome: A Case Report
TLDR
An emphasis is given on progression of this life threatening condition, mode of death, responsibilities of the physician and legal as well as criminal consequences arise out of it while treating such cases.
The Genetics of Antiepileptic Drug–Induced Skin Reactions
Some antiepileptic drugs (AEDs) may cause allergic cutaneous reactions with significant morbidity and mortality, including Stevens–Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Many
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