Medical Marijuana and Chronic Pain: a Review of Basic Science and Clinical Evidence

  title={Medical Marijuana and Chronic Pain: a Review of Basic Science and Clinical Evidence},
  author={Bj{\o}rn Jensen and Jeffrey Chen and Timothy J. Furnish and Mark S Wallace},
  journal={Current Pain and Headache Reports},
Cannabinoid compounds include phytocannabinoids, endocannabinoids, and synthetics. The two primary phytocannabinoids are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), with CB1 receptors in the brain and peripheral tissue and CB2 receptors in the immune and hematopoietic systems. The route of delivery of cannabis is important as the bioavailability and metabolism are very different for smoking versus oral/sublingual routes. Gold standard clinical trials are limited; however, some… 
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