Medical Management of Adult Transsexual Persons

  title={Medical Management of Adult Transsexual Persons},
  author={Emily L Knezevich and Laura K. Viereck and Andjela Drincic},
  journal={Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy},
Gender identity disorder (GID), or transsexualism, is an increasingly recognized medical condition with an expanding body of medical literature to support the use of established therapeutic guidelines. Transsexualism can be effectively managed through exogenous cross‐sex hormone administration used to induce development of desired sex characteristics, as well as use of other agents, such as aldosterone antagonists, aimed at decreasing physical characteristics of the undesired sex. Many… 
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Although there is currently considerable focus on sexually transmitted infections in the MTF transgender population, a more comprehensive approach to health care is required, including education for transgender people and the health professionals who attend to them regarding appropriate hormone therapy.
Endocrine care of transpeople part I. A review of cross‐sex hormonal treatments, outcomes and adverse effects in transmen
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Hormonal Therapy of the female to male transition (FTM) is focused only on people who transit from woman to man, or male trans, male transgender.
Hormonal, Medical, and Nonsurgical Aspects of Gender Affirmation.


Endocrine treatment of transsexual people: a review of treatment regimens, outcomes, and adverse effects.
The range of treatment used by transsexual people, the rationale behind these, and the expectation from such treatment are discussed, as well as the potential adverse effects of cross-sex hormone treatment of transsexual people.
Endocrine treatment of transsexual persons: an Endocrine Society clinical practice guideline.
This evidence-based guideline was developed using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) system to describe the strength of recommendations and the quality of evidence, which was low or very low.
Long-term treatment of transsexuals with cross-sex hormones: extensive personal experience.
Cross-sex hormone treatment of transsexuals seems acceptably safe over the short and medium term, but solid clinical data are lacking.
Hormone Treatment of the Adult Transsexual Patient
  • L. Gooren
  • Medicine, Biology
    Hormone Research in Paediatrics
  • 2005
The goal of treatment in female-to-male transsexuals is to induce virilization, including a male pattern of sexual hair, a male voice and male physical contours, and to stop menses.
Endocrine intervention for transsexuals
This review discusses predisposing factors to transsexualism, and the diagnosis, assessment and hormone treatment of transsexual patients, and discusses the risks and organ-specific effects of crosssex hormone treatment.
Endocrine treatment of male-to-female transsexuals using gonadotropin-releasing hormone agonist.
It is concluded that cross-sex hormone treatment of male-to-female transsexuals using GnRHa and oestradiol-17beta valerate is effective, and side effects and complication rates can be reduced using the treatment regimen presented here.
Providing Care to Transgender Persons: A Clinical Approach to Primary Care, Hormones, and HIV Management
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  • Medicine
    The Journal of the Association of Nurses in AIDS Care : JANAC
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A Follow-Up Study for Estimating the Effectiveness of a Cross-Gender Hormone Substitution Therapy on Transsexual Patients
With the cross-gender hormone regimen performed by the authors it is possible to generate less side effects in the treatment of transsexual patients than described before.
Hormone-related tumors in transsexuals receiving treatment with cross-sex hormones.
The probability of a hormone-related tumor increases with the duration of exposure to cross-sex hormones and the aging of the population of transsexuals, so far only a few cases of hormone- related cancer in transsexuals are encountered.
Endocrine Therapy of Transsexualism and Potential Complications of Long-Term Treatment
It is clear that estrogen as well as androgen therapy have a dual role: induction of feminization or virilization and suppression of the hypothalamic-pituitary-gonadal axis leading to a reduction of endogenous estradiol or testosterone secretion.