Medical Advances in the Treatment of Postpartum Hemorrhage

@article{DucloyBouthors2014MedicalAI,
  title={Medical Advances in the Treatment of Postpartum Hemorrhage},
  author={A.-S. Ducloy-Bouthors and Sophie Susen and Cynthia A Wong and Alexander J. Butwick and Beno{\^i}t Vallet and Evelyn L Lockhart},
  journal={Anesthesia \& Analgesia},
  year={2014},
  volume={119},
  pages={1140–1147}
}
Postpartum hemorrhage (PPH) is a leading cause of maternal mortality worldwide. Recent advances in the management of severe bleeding for trauma patients may provide insight into PPH management, but must be applied with caution considering the significant differences between trauma and obstetric patients. In this review, we summarized evidence for current management strategies for patients with major obstetric hemorrhage, including (1) rapid laboratory assessment of coagulopathy, (2) early… Expand
Postpartum hemorrhage: a continuing challenge.
  • E. Lockhart
  • Medicine
  • Hematology. American Society of Hematology. Education Program
  • 2015
TLDR
The epidemiology of PPH as well as current recommendations for key elements in obstetric hemorrhage protocols are examined, including recognition of hypofibrinogenemia as a risk factor for severe PPH, use of antifibrinolytic therapy, and strategies for fibrinogens replacement therapy. Expand
Massive obstetric hemorrhage: Current approach to management.
TLDR
Using massive obstetric hemorrhage protocols is useful for facilitating rapid transfusion if needed, and can also be cost-effective, if hypofibrinogenemia during the bleeding episode is identified, early fibr inogen administration can be very useful. Expand
Massive obstetric hemorrhage: Current approach to management.
TLDR
Using massive obstetric hemorrhage protocols is useful for facilitating rapid transfusion if needed, and can also be cost-effective, if hypofibrinogenemia during the bleeding episode is identified, early fibr inogen administration can be very useful. Expand
Trends in Postpartum Hemorrhage in the United States From 2010 to 2014
TLDR
There was a decline in associated coagulopathy, acute respiratory failure, and maternal death, but an increase in sepsis and acute renal failure among patients with PPH, and continued focus on PPH management is warranted. Expand
Major obstetric hemorrhage.
  • A. Le Gouez, F. Mercier
  • Medicine
  • Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine
  • 2016
Major obstetric hemorrhage is a challenge for anesthesiologists because it remains responsible for over 10% of maternal deaths in high-income countries. A standardized multidisciplinary management,Expand
Other new players in medical management of postpartum hemorrhage?
TLDR
The article elegantly presented strategies for early laboratory diagnosis and addressed transfusion protocols and pharmacologic interventions to improve maternal outcomes, it was surprised that the pharmacological segment failed to mention: (a) the impact of newer uterotonic carbetocin and (b) the role of recombinant factor VIIa (rFVIIa) in obstetric hemorrhage. Expand
Successful Hysterectomy and Therapeutic Hypothermia Following Cardiac Arrest due to Postpartum Hemorrhage
TLDR
A 41-year-old pregnant woman underwent a cesarean section under general anesthesia at 37 weeks of gestation, and experienced massive postpartum bleeding, which led to cardiac arrest, and was placed under therapeutic hypothermia management. Expand
Collaborative Strategies for Management of Obstetric Hemorrhage.
Obstetric hemorrhage is a significant cause of perinatal morbidity and mortality that requires prompt recognition and collaborative intervention to prevent poor outcomes. Medical and surgicalExpand
The diagnosis and management of morbidly adherent placenta.
TLDR
It is important for clinicians to screen all pregnancies for MAP at the time of routine second-trimester ultrasonography and patients with risk factors (e.g., multiple prior cesarean deliveries) should undergo targeted screening for MAP. Expand
Anesthetic and Obstetric Management of Placenta Accreta: Clinical Experience and Available Evidence
TLDR
This article reviews anesthetic and obstetric management of patients with placenta accreta based on clinician experience and the current literature, with emphasis on several controversial aspects of care, including timing of delivery, whether and when conservative Obstetric management should be considered, the role of perioperative interventional radiology, and the risks and benefits of general versus neuraxial anesthesia. Expand
...
1
2
3
4
...

References

SHOWING 1-10 OF 102 REFERENCES
How we treat: management of life‐threatening primary postpartum hemorrhage with a standardized massive transfusion protocol
TLDR
The implementation of a standardized massive transfusion protocol for the labor and delivery department at this institution after a maternal death caused by amniotic fluid embolism and the successful management of three cases of massive primary postpartum hemorrhage are described. Expand
Postpartum hemorrhage: When uterotonics and sutures fail
TLDR
Coagulation laboratory evaluation may be useful in guiding hemostatic management during massive PPH, but for the results to be useful, they must be rapidly available and provide information that would not be available from clinical assessment alone. Expand
Algorithm-based coagulation management of catastrophic amniotic fluid embolism
TLDR
Stable clotting situation was maintained despite further clinical deterioration and development of multiple organ failure in this patient, and an algorithm-based approach in managing coagulopathy and hemorrhage in a fatal case of histopathologically proven AFE is presented. Expand
An Observational Study of the Fresh Frozen Plasma: Red Blood Cell Ratio in Postpartum Hemorrhage
TLDR
A higher FFP:RBC ratio was associated with a lower requirement for advanced interventional procedures in the setting of postpartum hemorrhage, and the benefits of transfusion using a higher F FP:R BC ratio should be confirmed by randomized-controlled trials. Expand
Postpartum hemorrhage treated with a massive transfusion protocol at a tertiary obstetric center: a retrospective study.
TLDR
The authors' massive transfusion protocol provides early access to red blood cells, plasma and platelets for patients experiencing unanticipated or severe postpartum hemorrhage, and favorable hematologic indices were observed post resuscitation. Expand
The decrease of fibrinogen is an early predictor of the severity of postpartum hemorrhage
TLDR
Findings indicate that a simple fibrinogen measurement can anticipate the risk of severe bleeding in PPH. Expand
Predictive factors of advanced interventional procedures in a multicentre severe postpartum haemorrhage study
TLDR
Five independent predictors of the need for an AIP in patients with SPPH and persistent bleeding are identified and using these predictors in a single score could be a reliable screening tool in patients at risk of persistent genital tract bleeding and needing an Aip. Expand
The FIB-PPH trial: fibrinogen concentrate as initial treatment for postpartum haemorrhage: study protocol for a randomised controlled trial
TLDR
The FIB-PPH trial aims to provide an evidence-based platform for the recommendations of the early use of fibrinogen concentrate in PPH, and investigates a 33% reduction in the need for blood transfusion in women suffering severe PPH. Expand
The Epidemiology of Postpartum Hemorrhage in a Large, Nationwide Sample of Deliveries
TLDR
PPH caused by uterine atony resulting in transfusion often occurs in the absence of recognized risk factors and is associated with substantial maternal morbidity and mortality. Expand
Evaluation and management of postpartum hemorrhage: consensus from an international expert panel
Postpartum hemorrhage (PPH) remains one of the leading causes of maternal morbidity and mortality worldwide, although the lack of a precise definition precludes accurate data of the absoluteExpand
...
1
2
3
4
5
...