Mediatory role of endothelium-derived nitric oxide in renal vasodilatory and excretory effects of bradykinin.

@article{Lahera1991MediatoryRO,
  title={Mediatory role of endothelium-derived nitric oxide in renal vasodilatory and excretory effects of bradykinin.},
  author={Vicente Lahera and Miguel Garc{\'i}a Salom and Mary J. Fiksen-Olsen and Juan Carlos Cant{\'o}n Romero},
  journal={American journal of hypertension},
  year={1991},
  volume={4 3 Pt 1},
  pages={
          260-2
        }
}
Intrarenal infusions of 5 ng/kg/min bradykinin (BK) in 5 mg/kg intravenous bolus meclofenamate-treated anesthetized dogs significantly increased renal blood flow, diuresis, natriuresis, and kaliuresis. All these effects were abolished by the simultaneous intrarenal infusion of a competitive inhibitor of nitric oxide synthesis, NG-monomethyl-L-arginine (LNMMA). Furthermore, the intrarenal infusion of this inhibitor alone also produced a significant decrease in basal renal blood flow. The… CONTINUE READING
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