Mediators of the biphasic responses of bone to intermittent and continuously administered parathyroid hormone.

Abstract

Parathyroid hormone (PTH) has biphasic effects on bone: continuous treatment is catabolic whereas intermittent treatment is anabolic. The mechanism(s) responsible for these differing effects are still unclear, partly because of the previous non-availability of a model system in which effects on both formation and resorption indices could be studied… (More)

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@article{Locklin2003MediatorsOT, title={Mediators of the biphasic responses of bone to intermittent and continuously administered parathyroid hormone.}, author={Rachel M. Locklin and Sundeep Khosla and Russell T. Turner and B. Lawrence Riggs}, journal={Journal of cellular biochemistry}, year={2003}, volume={89 1}, pages={180-90} }