Mediators of inflammation and their interaction with sleep: relevance for chronic fatigue syndrome and related conditions.

@article{Mullington2001MediatorsOI,
  title={Mediators of inflammation and their interaction with sleep: relevance for chronic fatigue syndrome and related conditions.},
  author={Janet M. Mullington and Dunja Hinze-Selch and Thomas Pollm{\"a}cher},
  journal={Annals of the New York Academy of Sciences},
  year={2001},
  volume={933},
  pages={
          201-10
        }
}
In humans, activation of the primary host defense system leads to increased or decreased NREM sleep quality, depending on the degree of early immune activation. Modest elevations of certain inflammatory cytokines are found during experimental sleep loss in humans and, in addition, relatively small elevations of cytokines are seen following commencement of pharmacological treatments with clozapine, a CNS active antipsychotic agent, known to have immunomodulatory properties. Cytokines such as TNF… CONTINUE READING

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