Mediators of induced pluripotency and their role in cancer cells - current scientific knowledge and future perspectives.

@article{Bernhardt2012MediatorsOI,
  title={Mediators of induced pluripotency and their role in cancer cells - current scientific knowledge and future perspectives.},
  author={Mathias Bernhardt and Marta Galach and Daniel Novak and Jochen Sven Utikal},
  journal={Biotechnology journal},
  year={2012},
  volume={7 6},
  pages={
          810-21
        }
}
The discovery that overexpression of the transcription factors Oct4, Sox2, Klf4 and c-Myc reprograms differentiated cells into "induced pluripotent stem cells" (iPSCs) has extended our understanding of mechanisms required to maintain stem cell pluripotency and to drive differentiation. Subsequently, additional factors have been discovered that are able to induce a pluripotent state. Recently several groups have succeeded in reprogramming cancer cells to iPSC-like induced pluripotent cancer… CONTINUE READING
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