Mediators of anaphylaxis but not activated neutrophils augment cholinergic responses of equine small airways.

@article{Olszewski1999MediatorsOA,
  title={Mediators of anaphylaxis but not activated neutrophils augment cholinergic responses of equine small airways.},
  author={Michal A Olszewski and Norman Edward Robinson and Feng-xia Zhu and X Y Zhang and Patricia K. Tithof},
  journal={American journal of physiology. Lung cellular and molecular physiology},
  year={1999},
  volume={276 3},
  pages={L522-L529}
}
Neutrophilic inflammation in small airways (SA) and bronchospasm mediated via muscarinic receptors are features of chronic obstructive pulmonary disease in horses (COPD). Histamine, serotonin, and leukotrienes (LTs) are reported to be involved in the exacerbation of COPD, and currently, histamine has been shown to increase tension response to electrical field simulation (EFS) in equine SA. We tested the effects of these mediators and the effects of activated neutrophils on the cholinergic… CONTINUE READING

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