Mediators of Injury and Inflammation

@article{Schlag1996MediatorsOI,
  title={Mediators of Injury and Inflammation},
  author={G{\"u}nther Schlag and Heinz Redl},
  journal={World Journal of Surgery},
  year={1996},
  volume={20},
  pages={406-410}
}
Mediators play a key role in the development of systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome, and multiple organ failure of vital organs. In this short review, we update our knowledge on these mediator networks. First, we summarize the stimuli that occur during severe trauma (intraoperative stress), including polymorphonuclear neutrophil-derived tissue-damaging substances, complement activation products, and adherence molecules such as selectins. The gut… CONTINUE READING

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