Mediator subunits MED1 and MED24 cooperatively contribute to pubertal mammary gland development and growth of breast carcinoma cells.

@article{Hasegawa2012MediatorSM,
  title={Mediator subunits MED1 and MED24 cooperatively contribute to pubertal mammary gland development and growth of breast carcinoma cells.},
  author={Natsumi Hasegawa and Akiko Sumitomo and Azusa Fujita and Nami Aritome and Shumpei Mizuta and Keiji Matsui and Ruri Ishino and Kana Inoue and Norinaga Urahama and Junko Nose and Toru Mukohara and S Kamoshida and Robert G Roeder and Mitsuhiro Ito},
  journal={Molecular and cellular biology},
  year={2012},
  volume={32 8},
  pages={1483-95}
}
The Mediator subunit MED1 is essential for mammary gland development and lactation, whose contribution through direct interaction with estrogen receptors (ERs) is restricted to involvement in pubertal mammary gland development and luminal cell differentiation. Here, we provide evidence that the MED24-containing submodule of Mediator functionally communicates specifically with MED1 in pubertal mammary gland development. Mammary glands from MED1/MED24 double heterozygous knockout mice showed… CONTINUE READING