Mediator promotes CENP-a incorporation at fission yeast centromeres.

Abstract

At Schizosaccharomyces pombe centromeres, heterochromatin formation is required for de novo incorporation of the histone H3 variant CENP-A(Cnp1), which in turn directs kinetochore assembly and ultimately chromosome segregation during mitosis. Noncoding RNAs (ncRNAs) transcribed by RNA polymerase II (Pol II) directs heterochromatin formation through not only… (More)
DOI: 10.1128/MCB.00374-12

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@article{Carlsten2012MediatorPC, title={Mediator promotes CENP-a incorporation at fission yeast centromeres.}, author={Jonas O. P. Carlsten and Zsolt Szil{\'a}gyi and Beidong Liu and Marcela D{\'a}vila L{\'o}pez and Erzs{\'e}bet Sz{\'a}szi and Ingela Djupedal and Thomas Nystr{\"o}m and Karl Ekwall and Claes Gustafsson and Xuefeng Zhu}, journal={Molecular and cellular biology}, year={2012}, volume={32 19}, pages={4035-43} }