Mediator influences telomeric silencing and cellular life span.

Abstract

The Mediator complex is required for the regulated transcription of nearly all RNA polymerase II-dependent genes. Here we demonstrate a new role for Mediator which appears to be separate from its function as a transcriptional coactivator. Mediator associates directly with heterochromatin at telomeres and influences the exact boundary between active and… (More)
DOI: 10.1128/MCB.05242-11

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