Mediator Subunit Gal11p/MED15 Is Required for Fatty Acid-dependent Gene Activation by Yeast Transcription Factor Oaf1p*

@article{Thakur2009MediatorSG,
  title={Mediator Subunit Gal11p/MED15 Is Required for Fatty Acid-dependent Gene Activation by Yeast Transcription Factor Oaf1p*},
  author={Jitendra Kumar Thakur and Haribabu Arthanari and Fajun Yang and Katherine H Chau and Gerhard Wagner and Anders M. N{\"a}{\"a}r},
  journal={Journal of Biological Chemistry},
  year={2009},
  volume={284},
  pages={4422 - 4428}
}
The yeast zinc cluster transcription factor Oaf1p activates transcription of target genes in response to direct binding of fatty acids in a manner analogous to the vertebrate nuclear receptor peroxisome proliferator-activated receptorα (PPARα). PPARs and other metazoan nuclear receptors productively engage several distinct LXXLL motif-containing co-activators, including p160 family members and the TRAP220/MED1 subunit of the Mediator co-activator, to promote ligand-dependent gene activation… 

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