Mediator Head module structure and functional interactions

  title={Mediator Head module structure and functional interactions},
  author={Gang Cai and Tsuyoshi Imasaki and Kentaro Yamada and Francesco Cardelli and Yuichiro Takagi and Francisco J. Asturias},
  journal={Nature Structural &Molecular Biology},
We used single-particle electron microscopy to characterize the structure and subunit organization of the Mediator Head module that controls Mediator–RNA polymerase II (RNAPII) and Mediator-promoter interactions. The Head module adopts several conformations differing in the position of a movable jaw formed by the Med18–Med20 subcomplex. We also characterized, by structural, biochemical and genetic means, the interactions of the Head module with TATA-binding protein (TBP) and RNAPII subunits… CONTINUE READING
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the mediator complex

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