Mediation of endogenous antioxidant enzymes and apoptotic signaling by resveratrol following muscle disuse in the gastrocnemius muscles of young and old rats.

@article{Jackson2010MediationOE,
  title={Mediation of endogenous antioxidant enzymes and apoptotic signaling by resveratrol following muscle disuse in the gastrocnemius muscles of young and old rats.},
  author={Janna R. Jackson and M. J. Ryan and Yanlei Hao and Stephen E. Alway},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2010},
  volume={299 6},
  pages={R1572-81}
}
Hindlimb suspension (HLS) elicits muscle atrophy, oxidative stress, and apoptosis in skeletal muscle. Increases in oxidative stress can have detrimental effects on muscle mass and function, and it can potentially lead to myonuclear apoptosis. Resveratrol is a naturally occurring polyphenol possessing both antioxidant and antiaging properties. To analyze the capacity of resveratrol to attenuate oxidative stress, apoptosis and muscle force loss were measured following 14 days of HLS. Young (6 mo… CONTINUE READING
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