Mediation of cell volume regulation by Ca2+ influx through stretch-activated channels

@article{Christensen1987MediationOC,
  title={Mediation of cell volume regulation by Ca2+ influx through stretch-activated channels},
  author={Ove Christensen},
  journal={Nature},
  year={1987},
  volume={330},
  pages={66-68}
}
Animal cells initially swell in hypotonic media by osmotic water equilibration, but their volume is subsequently regulated by a net loss of KCl and amino acids with concomitant loss of cell water1,2. Mechanisms for regulating cell volume are important in allowing cells to adapt to variations in external tonicity and metabolic load3. In red cells the KCl loss is mediated by electroneutral ion transport mechanisms4. In contrast, conductive K+ and Cl– transport pathways are activated during… CONTINUE READING