Mediation of apoptosis and proliferation of human embryonic stem cells by sphingosine-1-phosphate.

@article{Inniss2006MediationOA,
  title={Mediation of apoptosis and proliferation of human embryonic stem cells by sphingosine-1-phosphate.},
  author={Katie Inniss and Harry Moore},
  journal={Stem cells and development},
  year={2006},
  volume={15 6},
  pages={789-96}
}
Human embryonic stem (hES) cells replicate by the process of self-renewal while maintaining their pluripotency. This process may be regulated by several different pathways and is poorly understood. In this study, sphingosine-1-phosphate (S1P) receptors were localized on hES cells of several cell lines (Shef 1-6), and their presence was verified by RT (reverse transcriptase)-PCR and western blotting. Dual staining with the stem cell marker Tra-1-60 revealed the presence of S1P receptors on… CONTINUE READING

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