Mediation by nitric oxide of the stimulatory effects of ethanol on blood flow.

  title={Mediation by nitric oxide of the stimulatory effects of ethanol on blood flow.},
  author={Enrique Baraona and Lilia Shoichet and Khursheed P Navder and Charles S. Lieber},
  journal={Life sciences},
  volume={70 25},
The contribution of nitric oxide (NO) to the hemodynamic effects associated with alcohol oxidation was assessed in rats given either ethanol or water by gastric tube, with and without pre-treatment with either the NO synthase inhibitor N(omega)-monomethyl-L-arginine (L-NMMA; 15 mg/Kg i.p.) or the alcohol dehydrogenase inhibitor 4-methylpyrazole (4-MP; 82 mg/Kg i.p.). Alcohol increased plasma NO (measured with chemiluminescence) by 63%. This was prevented by either L-NMMA or 4-MP. Cardiac output… CONTINUE READING


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