Mediation by N-methyl- d-aspartate and non- N-methyl- d-aspartate receptors in the expression of fos protein at the nucleus tractus solitarii in response to baroreceptor activation in the rat

@article{Chan1998MediationBN,
  title={Mediation by N-methyl- d-aspartate and non- N-methyl- d-aspartate receptors in the expression of fos protein at the nucleus tractus solitarii in response to baroreceptor activation in the rat},
  author={Julie Y. H. Chan and Suk Min Yang and Samuel H. H. Chan},
  journal={Neuroscience},
  year={1998},
  volume={83},
  pages={93-105}
}
We investigated the role of glutamatergic synapses in the expression of Fos protein at the nucleus tractus solitarii following baroreceptor activation in rats anaesthetized with pentobarbital sodium. Microinjection of L-glutamate (1 nmol) bilaterally into the nucleus tractus solitarii elicited significant hypotension and bradycardia. There was a concurrent increase, as determined immunohistochemically, in the expression of Fos protein at the commissural, medial and dorsomedial subnuclei of the… Expand
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TLDR
A predominant role for NMDA but not for AMPA glutamate receptors in nTS mediated components of the hypoxic response is suggested. Expand
Role of calcium/calmodulin-dependent protein kinases in expression of Fos protein in the nucleus tractus solitarii after sustained hypertension
TLDR
Activation of calcium/calmodulin-dependent protein kinases may represent an important step in the cascade of intracellular events that leads to phosphorylation of cyclic AMP response element binding protein and subsequent induction of c-fos gene after activation of ionotropic glutamate receptors by baroceptive signals in the nucleus tractus solitarii. Expand
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Inhibition of Baroreflex by Angiotensin II via Fos Expression in Nucleus Tractus Solitarii of the Rat
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Parabrachial nucleus induces suppression of baroreflex bradycardia by the release of glutamate in the rostral ventrolateral medulla of the rat.
TLDR
An increase in the extracellular concentration of glutamate and activation of both NMDA and non-NMDA receptors in the RVLM may mediate the suppression of baroreflex bradycardia by activation of the parabrachial nucleus. Expand
Parabrachial Nucleus Induces Suppression of Baroreflex Bradycardia by the Release of Glutamate in the Rostral Ventrolateral Medulla of the Rat
The involvement of glutamatergic neurotransmission in the rostral ventrolateral medulla (RVLM) in the suppression of baroreflex bradycardia by the parabrachial nucleus (PBN) was investigated.Expand
Fos protein is required for the re-expression of angiotensin II type 1 receptors in the nucleus tractus solitarii after baroreceptor activation in the rat
TLDR
S sustained hypertension down-regulates angiotensin II subtype 1 receptors at both messenger RNA and functional expression levels in the nucleus tractus solitarii, and Fos protein induced by baroreceptor activation may play a permissive role in the transcriptional regulation of the re-expression of this subtype of angiotENSin receptors. Expand
Interaction between clonidine and N-methyl-D-aspartate receptors in the caudal ventrolateral medulla of rats
TLDR
Findings show that NMDA receptors within the CVLM contribute to clonidine-induced action, and suggest that the caudal ventrolateral medulla plays an important role in the interaction betweenClonidine andNMDA receptors. Expand
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