Mediation, modulation, and consequences of membrane-cytoskeleton interactions.

  title={Mediation, modulation, and consequences of membrane-cytoskeleton interactions.},
  author={Gary J. Doherty and Harvey T. McMahon},
  journal={Annual review of biophysics},
Elements of the cytoskeleton interact intimately and communicate bidirectionally with cellular membranes. Such interactions are critical for a host of cellular processes. Here we focus on the many types of interactions that exist between the cytoskeleton and the plasma membrane to illustrate why these cellular components can never truly be studied in isolation in vivo. We discuss how membrane-cytoskeleton interactions are mediated and modulated, and how many proteins involved in these… 

Figures from this paper

Plasma membrane--cortical cytoskeleton interactions: a cell biology approach with biophysical considerations.

The aim of this article is to provide an overview of the tight structural and functional coupling between the membrane and the cytoskeleton, and to focus on a few key physical parameters and processes that contribute to a variety of fundamental cell biological functions.

Protein–membrane interactions: the virtue of minimal systems in systems biology

Examples of how an emergent behavior of protein–membrane interactions has been demonstrated by the use of minimal systems are described to contribute to a deeper understanding of protein interactomes involving membranes and complement other approaches of systems biology.

Profilin as a regulator of the membrane-actin cytoskeleton interface in plant cells

Recent findings in plant cells are summarized, and the evidence of the connections among actin cytoskeleton, profilin and biomembranes through direct or indirect relationships is discussed.

Biomimetic membrane systems to study cellular organization.

Active organization of membrane constituents in living cells.

Control of cortical rigidity by the cytoskeleton: Emerging roles for septins

How septins may play this role, drawing on their physical form, their ability to directly bind and modify membranes and actomyosin, and their interactions with vesicular machinery are reviewed, may be relevant in multiple disease settings.

Modern views on the structure and dynamics of biological membranes

In the attempts to describe and model the properties of cellular membranes there is a timely necessity to shift from two-dimensionality (which reduces the analysis to membrane plane only) to more realistic three-dimensional models.

Structural Rearrangements in CHO Cells After Disruption of Individual Cytoskeletal Elements and Plasma Membrane

The results demonstrate that, besides the cytoskeleton, the plasma membrane is an important contributor to cellular integrity, possibly by acting as an essential framework for cytoskeletal anchoring, and support the notion of the cell as a prestressed structure.

Molecular Simulations of Protein-Induced Membrane Remodeling

This dissertation presents a series of molecular models which, when combined with continuum models and both in vitro and in vivo experiments, describe the molecular basis for membrane morphology changes, and investigates the mechanisms by which proteins assemble on a bilayer undergoing thermal fluctuations.

Ezrin is a Major Regulator of Membrane Tension in Epithelial Cells

The data confirm the importance of the ezrin-mediated connection between plasma membrane and cortex for cellular mechanics and cell morphology in confluent MDCK II cells.



Continuous membrane-cytoskeleton adhesion requires continuous accommodation to lipid and cytoskeleton dynamics.

The roles of the major phosphatidylinositol-4,5-diphosphate (PIP2) binding protein, MARCKS, and PIP2 levels in controlling cytoskeleton dynamics are considered and further understanding of dynamics will provide important clues about how membrane-cytoskeleton adhesion rapidly adjusts to cytos skeleton and membrane dynamics.

The cytoskeleton and cell volume regulation.

Actin polymerization serves as a membrane domain switch in model lipid bilayers.

The results show that dynamic, membrane-bound actin networks alone can control when and where membrane domains form and may actively contribute to membrane organization during cell signaling.

Phosphoinositides in cell regulation and membrane dynamics

Inositol phospholipids mediate acute responses, but also act as constitutive signals that help define organelle identity, and play a fundamental part in controlling membrane–cytosol interfaces.

Phosphoinositide regulation of the actin cytoskeleton.

This review presents tantalizing evidence that suggests how binding of selected cytoskeletal proteins to membrane PPIs may promote PPI clustering into raft lipid microdomains, alter their accessibility to other proteins, and even distort the bilayer conformation.

Regulated Interactions between Dynamin and the Actin-Binding Protein Cortactin Modulate Cell Shape

These findings provide the first demonstration that dynamin can interact with the actin cytoskeleton to regulate actin reorganization and subsequently cell shape.

Actin regulation in endocytosis

Live cell imaging indicates that spatiotemporal aspects of actin recruitment and vesicle formation are likely to be conserved across eukaryotic evolution.