MediatesL-Arginine – Induced Inhibition of Thick Ascending Limb Chloride Flux

@inproceedings{Plato2000MediatesLArginineI,
  title={MediatesL-Arginine – Induced Inhibition of Thick Ascending Limb Chloride Flux},
  author={Craig F. Plato and Edward G. Shesely and Jeffrey L. Garvin},
  year={2000}
}
We recently reported that the rat thick ascending limb (THAL) possesses an active isoform of nitric oxide synthase (NOS) that is substrate-limited in vitro. NO produced by THAL NOS inhibits chloride flux. Protein and transcript for each of the primary NOS isoforms 2endothelial (eNOS), inducible (iNOS), and neuronal (nNOS) 2have been demonstrated in THALs. However, the NOS isoform that mediates NO-induced inhibition of chloride flux is unknown. We hypothesized that NO produced from eNOS in the… CONTINUE READING

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