Mediates a cAMP-to-PKC Signaling in Inflammatory Pain : An Isolectin B 4 ( ) Neuron-Specific Mechanism

@inproceedings{Hucho2005MediatesAC,
  title={Mediates a cAMP-to-PKC Signaling in Inflammatory Pain : An Isolectin B 4 ( ) Neuron-Specific Mechanism},
  author={Tim B. Hucho and Olayinka A. Dina and Jon D Levine},
  year={2005}
}
The isoform of protein kinase C (PKC ) has emerged as a critical second messenger in sensitization toward mechanical stimulation in models of neuropathic (diabetes, alcoholism, and cancer therapy) as well as acute and chronic inflammatory pain. Signaling pathways leading to activation of PKC remain unknown. Recent results indicate signaling from cAMP to PKC. A mechanism connecting cAMP and PKC, two ubiquitous, commonly considered separate pathways, remains elusive. We found that, in cultured… CONTINUE READING